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Perspectives of long non-coding RNAs in cancer

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Abstract

A recent advance in transcriptomics has spawned the ‘Decade of non-coding RNAs’ by potentiating the growing numbers of long non-coding RNA in cancer. LncRNA involvement in cancer denotes its significance beyond our perception as they participate in tumor suppression and promoting oncogenesis, which raises them as a mighty class of effectors or regulators. Aberrantly expressed lncRNAs interact with major protein and coding partners, which ultimately deregulate normal cellular processes and drive the cell towards malignant state. Identification of theses interactions are utmost important as lncRNAs can be ideal targets for therapy. Dysregulation of lncRNAs by genomic alterations like single nucleotide variations and gene fusions are also potential modulators of their secondary structure. In this review, we discuss the various molecular interactions of lncRNAs with major bio-molecules and genetic variations in lncRNA genes and their importance in cancer. This systematic review outlines the vivid role of lncRNAs in cancer context and opens up future conceptual applications.

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Acknowledgements

This work was supported by Department of Biotechnology and Science & Engineering Research Board, Department of Science and Technology, Government of India, New Delhi, India.

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AKDMR and SM contributed to conception of the idea, literature search, drafting and editing of the manuscript. TR revised the manuscript with critical reviews and comments and all the authors approved the final version.

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  1. Department of Molecular Oncology, Cancer Institute (WIA), No:38, Sardar Patel Road, Adyar, Chennai, Tamil Nadu, 600036, India

    Arunagiri Kuha Deva Magendhra Rao, Thangarajan Rajkumar & Samson Mani

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  1. Arunagiri Kuha Deva Magendhra Rao
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Rao, A.K.D.M., Rajkumar, T. & Mani, S. Perspectives of long non-coding RNAs in cancer. Mol Biol Rep 44, 203–218 (2017). https://doi.org/10.1007/s11033-017-4103-6

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