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−765G>C and 8473T>C polymorphisms of COX-2 and cancer risk: a meta-analysis based on 33 case–control studies

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Abstract

Cyclooxygenase-2 (COX-2) is an inducible enzyme converting arachidonic acid to prostaglandins and playing important roles in cancer etiology. The −765G>C and 8473T>C polymorphisms have been implicated in cancer risk. However, the results on the association between the two COX-2 polymorphisms and cancer risk are conflicting. To derive a more precise estimation of the association between them, we performed a meta-analysis of 8,090 cancer cases and 11,010 controls concerning −765G>C polymorphism and 14,283 cancer cases and 15,489 controls concerning 8473T>C polymorphism from 33 case–control studies. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Overall, individuals with the −765GC or GC/CC genotypes were associated with higher cancer risk than those with the −765GG genotype and in the stratified analysis this effect maintained in colorectal carcinoma or esophageal cancer of Asian descents. Overall, no significant cancer risk of 8473T>C polymorphism was found. Stratified by cancer types, the variant 8473CC was associated with a decreased risk in breast cancer, compared with the TT or TC/TT genotypes and in lung cancer subgroup after sensitive analysis, there was a decreased risk in CC versus TT, TC versus TT and the dominant models. Moreover, a decreased risk of lung cancer was observed among smokers in the dominant model. In summary, this meta-analysis suggesting that −765G>C may cause an increased risk of colorectal carcinoma and esophageal cancer in Asian descents while 8473T>C polymorphism may cause a decreased risk of breast and lung cancer.

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Abbreviations

OR:

Odds ratio

CI:

Confidence interval

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Authors and Affiliations

  1. Department of Oncology, First Affiliated Hospital of Nanjing Medical University, No. 300 Guang Zhou Road, Nanjing, 210029, China

    Wei Zhu & Ping Liu

  2. Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    Bing-bing Wei

  3. Department of Respiration, First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    Xia Shan

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  1. Wei Zhu
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  2. Bing-bing Wei
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  3. Xia Shan
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  4. Ping Liu
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Correspondence to Ping Liu.

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Wei Zhu, Bing-bing Wei, Xia Shan and Ping Liu authors have contributed equally to this work.

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Zhu, W., Wei, Bb., Shan, X. et al. −765G>C and 8473T>C polymorphisms of COX-2 and cancer risk: a meta-analysis based on 33 case–control studies. Mol Biol Rep 37, 277–288 (2010). https://doi.org/10.1007/s11033-009-9685-1

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