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Arsenic trioxide and neuroblastoma cytotoxicity

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Abstract

The majority of aggressive forms of the childhood tumor neuroblastoma can with current treatment protocols not be cured and possess a major challenge in pediatric oncology. After initial rounds of chemotherapy, surgery and irradiation, which in most cases result in tumor regression, these aggressive neuroblastomas relapse and frequently develop drug resistance. As approximately 50% of the children with neuroblastoma have an aggressive form, there is a compelling demand for new treatment strategies. Arsenic trioxide has the capacity to kill multidrug-resistant neuro-blastoma cells in vitro and in vivo and the drug is currently being evaluated in clinical trials. In this report we discuss the background to the use of arsenic trioxide in cancer therapy and the currently known mechanisms by which arsenic trioxide kills human neuroblastoma cells.

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References

  • Akao Y, Nakagawa Y, Akiyama K (1999) FEBS Lett 455:59–62

    Google Scholar 

  • Amadori S, Fenaux P, Ludwig H, O’Dwyer M, Sanz M (2005) Curr Med Res Opin 21:403–411

    Google Scholar 

  • Brizel DM, Scully SP, Harrelson JM, Layfield LJ, Bean JM, Prosnitz LR, Dewhirst MW (1996) Cancer Res 56:941–943

    Google Scholar 

  • Brodeur GM, Pritchard J, Berthold F, Carlsen NL, Castel V, Castelberry RP, De Bernardi B, Evans AE, Favrot M, Hedborg F et al (1993) J Clin Oncol 11:1466–1477

    Google Scholar 

  • Cai X, Shen YL, Zhu Q, Jia PM, Yu Y, Zhou L, Huang Y, Zhang JW, Xiong SM, Chen SJ, Wang ZY, Chen Z, Chen GQ (2000) Leukemia 14:262–270

  • Cao X, Deng X, May WS (2003) Blood 102:2605–2614

  • Cartron PF, Oliver L, Juin P, Meflah K, Vallette FM (2004) J Biol Chem 279:11503–11512

    Google Scholar 

  • Chen GQ, Shi XG, Tang W, Xiong SM, Zhu J, Cai X, Han ZG, Ni JH, Shi GY, Jia PM, Liu MM, He KL, Niu C, Ma J, Zhang P, Zhang TD, Paul P, Naoe T, Kitamura K, Miller W, Waxman S, Wang ZY, de The H, Chen SJ, Chen Z (1997) Blood 89:3345–3353

  • Chen GQ, Zhu J, Shi XG, Ni JH, Zhong HJ, Si GY, Jin XL, Tang W, Li XS, Xong SM, Shen ZX, Sun GL, Ma J, Zhang P, Zhang TD, Gazin C, Naoe T, Chen SJ, Wang ZY, Chen Z (1996) Blood 88:1052–1061

  • Choi WS, Lee EH, Chung CW, Jung YK, Jin BK, Kim SU, Oh TH, Saido TC,Oh YJ (2001) J Neurochem 77:1531–1541

    Google Scholar 

  • Cohen MH, Hirschfeld S, Flamm Honig S, Ibrahim A, Johnson JR, O’Leary JJ, White RM, Williams GA, Pazdur R (2001) Oncologist 6:4–11

    Google Scholar 

  • Dai J, Weinberg RS, Waxman S, Jing Y (1999) Blood 93:268–277

    Google Scholar 

  • Deaglio S, Canella D, Baj G, Arnulfo A, Waxman S, Malavasi F (2001) Leuk Res 25:227–235

    Google Scholar 

  • Gao G, Dou QP (2000). J Cell Biochem 80:53–72

    Google Scholar 

  • Hoehner JC, Gestblom C, Hedborg F, Sandstedt B, Olsen L, Pahlman S (1996) Lab Invest 75:659–675

    Google Scholar 

  • Jiang XH, Wong BC, Yuen ST, Jiang SH, Cho CH, Lai KC, Lin MC, Kung HF, Lam SK, Chun-Yu Wong B (2001) Int J Cancer 91:173–179

  • Jing Y, Dai J, Chalmers-Redman RM, Tatton WG, Waxman S (1999) Blood 94:2102–2111

    Google Scholar 

  • Kanzawa T, Kondo Y, Ito H, Kondo S, Germano I (2003) Cancer Res 63:2103–2108

    Google Scholar 

  • Karlsson J, Edsjo A, Påhlman S, Pettersson HM (2005) Mol Cancer Ther 4:1128–1135

    Google Scholar 

  • Karlsson J, Øra I, Pörn-Ares I, Påhlman S (2004) Clin Cancer Res 10:3179–3188

    Google Scholar 

  • Keshelava N, Seeger RC, Groshen S, Reynolds CP (1998) Cancer Res 58:5396–5405

    Google Scholar 

  • Keshelava N, Zuo JJ, Chen P, Waidyaratne SN, Luna MC, Gomer CJ, Triche TJ, Reynolds CP (2001) Cancer Res 61:6185–6193

    Google Scholar 

  • Kitamura K, Minami Y, Yamamoto K, Akao Y, Kiyoi H, Saito H, Naoe T (2000) Leukemia 14:1743–1750

    Google Scholar 

  • Lallemand-Breitenbach V, Guillemin MC, Janin A, Daniel MT, Degos L, Kogan SC, Bishop JM, de The H (1999) J Exp Med 189:1043–1052

    Google Scholar 

  • Larochette N, Decaudin D, Jacotot E, Brenner C, Marzo I, Susin SA, Zamzami N, Xie Z, Reed J, Kroemer G (1999) Exp Cell Res 249:413–421

    Google Scholar 

  • Mathews V, Balasubramanian P, Shaji RV, George B, Chandy M, Srivastava A (2002) Am J Hematol 70:292–299

    Google Scholar 

  • Matthay KK, Villablanca JG, Seeger RC, Stram DO, Harris RE, Ramsay NK, Swift P, Shimada H, Black CT, Brodeur GM, Gerbing RB, Reynolds CP (1999) N Engl J Med 341:1165–1173

    Google Scholar 

  • McCafferty-Grad J, Bahlis NJ, Krett N, Aguilar TM, Reis I, Lee KP, Boise LH (2003) Mol Cancer Ther 2:1155–2264

    Google Scholar 

  • Miller TM, Moulder KL, Knudson CM, Creedon DJ, Deshmukh M, Korsmeyer SJ, Johnson EM Jr (1997) J Cell Biol 139:205–217

    Google Scholar 

  • Niu C, Yan H, Yu T, Sun HP, Liu JX, Li XS, Wu W, Zhang FQ, Chen Y, Zhou L, Li JM, Zeng XY, Yang RR, Yuan MM, Ren MY, Gu FY, Cao Q, Gu BW, Su XY, Chen GQ, Xiong SM, Zhang T, Waxman S, Wang ZY, Chen SJ, et al (1999) Blood 94:3315–3324

  • Panaretakis T, Pokrovskaja K, Shoshan MC, Grander D (2002) J Biol Chem 277:44317–44326

    Google Scholar 

  • Pennacchietti S, Michieli P, Galluzzo M, Mazzone M, Giordano S, Comoglio PM (2003) Cancer Cell 3:347–61

    Google Scholar 

  • Philip T, Ladenstein R, Lasset C, Hartmann O, Zucker JM, Pinkerton R, Pearson AD, Klingebiel T, Garaventa A, Kremens B, Bernard JL, Rosti G, Chauvin F (1997) Eur J Cancer 33:2130–2135

    Google Scholar 

  • Quignon F, De Bels F, Koken M, Feunteun J, Ameisen JC, de The H (1998) Nat Genet 20:259–265

    Google Scholar 

  • Ratnaike RN (2003) Postgrad Med J 79:391–396

    Google Scholar 

  • Roboz GJ, Dias S, Lam G, Lane WJ, Soignet SL, Warrell RP Jr, Rafii S (2000) Blood 96:1525–1530

    Google Scholar 

  • Rojewski MT, Baldus C, Knauf W, Thiel E, Schrezenmeier H (2002) Br J Haematol 116:555–563

    Google Scholar 

  • Rojewski MT, Korper S, Schrezenmeier H (2004) Leuk Lymphoma 45:2387–2401

    Google Scholar 

  • Schlappack OK, Zimmermann A, Hill RP (1991) Br J Cancer 64:663–670

    Google Scholar 

  • Shannon AM, Bouchier-Hayes DJ, Condron CM, Toomey D (2003) Cancer Treat Rev 29:297–307

    Google Scholar 

  • Shen ZX, Chen GQ, Ni JH, Li XS, Xiong SM, Qiu QY, Zhu J, Tang W, Sun GL, Yang KQ, Chen Y, Zhou L, Fang ZW, Wang YT, Ma J, Zhang P, Zhang TD, Chen SJ, Chen Z, Wang ZY (1997) Blood 89:3354–3360

  • Shen ZX, Shi ZZ, Fang J, Gu BW, Li JM, Zhu YM, Shi JY, Zheng PZ, Yan H, Liu YF, Chen Y, Shen Y, Wu W, Tang W, Waxman S, De The H, Wang ZY, Chen SJ, Chen Z (2004) Proc Natl Acad Sci (U. S. A.) 101:5328–5335

    Google Scholar 

  • Soignet SL, Frankel SR, Douer D, Tallman MS, Kantarjian H, Calleja E, Stone RM, Kalaycio M, Scheinberg DA, Steinherz P, Sievers EL, Coutre S, Dahlberg S, Ellison R, Warrell RP Jr (2001) J Clin Oncol 19:3852–3860

    Google Scholar 

  • Soignet SL, Maslak P, Wang ZG, Jhanwar S, Calleja E, Dardashti LJ, Corso D, DeBlasio A, Gabrilove J, Scheinberg DA, Pandolfi PP and Warrell RP Jr (1998) N Engl J Med 339:1341–1348

    Google Scholar 

  • Sun HD, Ma L, Hu XC, Zhang TD (1992) Chin J Integrat Chin West Med 12:170–172

    Google Scholar 

  • Teicher BA (1994) Cancer Metastasis Rev 13:139–168

    Google Scholar 

  • Teitz T, Wei T, Valentine MB, Vanin EF, Grenet J, Valentine VA, Behm FG, Look AT, Lahti JM, Kidd VJ (2000) Nat Med 6:529–535

    Google Scholar 

  • Toyota H, Yanase N, Yoshimoto T, Moriyama M, Sudo T, Mizuguchi J (2003) Cancer Lett 189:221–230

    Google Scholar 

  • Tweddle DA, Malcolm AJ, Bown N, Pearson AD, Lunec J (2001) Cancer Res 61:8–13

    Google Scholar 

  • Waxman S, Andersson KC (2001) The Oncologist 6:3–10

  • Wood DE, Newcomb EW (2000) Exp Cell Res 256:375–382

    Google Scholar 

  • Wood DE, Thomas A, Devi LA, Berman Y, Beavis RC, Reed JC, Newcomb EW (1998) Oncogene 17:1069–1078

    Google Scholar 

  • Xiang J, Chao DT, Korsmeyer SJ (1996) Proc Natl Acad Sci (U S A) 93:14559–14563

    Google Scholar 

  • Zheng Y, Shi Y, Tian C, Jiang C, Jin H, Chen J, Almasan A, Tang H, Chen Q (2004) Oncogene 23:1239–1247

  • Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, Simons JW (1999) Cancer Res 59:5830–1535

    Google Scholar 

  • Zhu XH, Shen YL, Jing YK, Cai X, Jia PM, Huang Y, Tang W, Shi GY, Sun YP, Dai J, Wang ZY, Chen SJ, Zhang TD, Waxman S, Chen Z, Chen GQ (1999) J Natl Cancer Inst 91:772–778

    Google Scholar 

  • Øra I, Bondesson L, Jonsson C, Ljungberg J, Porn-Ares I, Garwicz S, Påhlman S (2000) Biochem Biophys Res Commun 277:179–85

    Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, University Hospital MAS, Malmö, Sweden

    Helen M. Pettersson, Jenny Karlsson, Alexander Pietras, Ingrid Øra & Sven Påhlman

  2. Department of Pediatric Oncology and Hematology, Lund University Hospital, Lund, Sweden

    Ingrid Øra

  3. Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, University Hospital MAS, Entrance 78, SE-205 02, Malmö, Sweden

    Sven Påhlman

Authors
  1. Helen M. Pettersson
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  2. Jenny Karlsson
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  3. Alexander Pietras
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  4. Ingrid Øra
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  5. Sven Påhlman
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Correspondence to Sven Påhlman.

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Pettersson, H.M., Karlsson, J., Pietras, A. et al. Arsenic trioxide and neuroblastoma cytotoxicity. J Bioenerg Biomembr 39, 35–41 (2007). https://doi.org/10.1007/s10863-006-9058-6

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