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The Incidence of Lynch Syndrome

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Abstract

Lynch syndrome (LS) here is defined as carriership of a deleterious mismatch repair (MMR) gene mutation. By screening for MMR gene mutations in unselected colorectal or endometrial cancer patients, it was found that the prevalence of LS in colorectal and endometrial cancer patients is 1–3%. On extrapolation to the entire population, the incidence of LS is between 1:2000 and 1:660. As all screening methods are less than 100% sensitive, the above figures are underestimates.

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Authors and Affiliations

  1. Professor and Director, Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, 420 W. 12th Avenue, 43210, Columbus, Ohio, 43210, USA

    Albert de la Chapelle

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  1. Albert de la Chapelle
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de la Chapelle, A. The Incidence of Lynch Syndrome. Familial Cancer 4, 233–237 (2005). https://doi.org/10.1007/s10689-004-5811-3

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