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Prognostic significance of platelet-derived growth factor receptor-β expression in localized clear cell renal cell carcinoma

  • Original Article – Clinical Oncology
  • Published:
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Abstract

Purpose

We investigated the expression status of vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF)-B and their receptors in organ-confined clear cell renal cell carcinoma (ccRCC) to evaluate their prognostic significance after radical surgery.

Methods

In 758 consecutive patients diagnosed with pT1-2N0 ccRCC between 2007 and 2012, we prospectively investigated the expression levels of VEGF, PDGF-B, VEGF receptor (VEGFR) and PDGF receptor (PDGFR)-β via immunohistochemistry. Clinicopathologic parameters and expression of the angiogenic factors were analyzed with respect to recurrence-free survival (RFS) after nephrectomy. The median follow-up was 29.5 months (IQR 21.5, 39.6) after surgery.

Results

Partial nephrectomy had been performed in 48.5 % of the patients, and tumors were staged as pT1a in 514 (67.8 %), pT1b in 192 (25.3 %) and pT2 in 52 (6.9 %). VEGF, PDGF and their receptors were identified in the cytoplasm and membranes of the tumor cells. Expression level of VEGFR inversely correlated with both tumor size (r = −0.076, p = 0.014) and nuclear grade (r = −0.297, p = 0.004). As for PDGF-B, the expression level showed an inverse correlation with tumor size (r = −0.216, p < 0.001) while PDGFR-β inversely correlated with nuclear grade (r = −0.341, p = 0.001). On multivariate analysis, age, pathologic stage, nuclear grade and PDGFR-β expression (high vs. low or none, HR 3.121 95 % CI 1.300–7.493, p = 0.011) were independently prognostic of RFS after nephrectomy.

Conclusions

In organ-confined ccRCC, high expression of PDGFR-β was independently predictive of poorer RFS after nephrectomy.

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Authors and Affiliations

  1. Department of Urology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, GyeongGi-Do, Korea

    Myungsun Shim

  2. Department of Urology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

    Cheryn Song, Choung-Soo Kim & Hanjong Ahn

  3. Department of Urology, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea

    Sejun Park

  4. Department of Urology, School of Medicine, Kyung Hee University, Seoul, Korea

    Seung-Kwon Choi

  5. Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

    Yong Mee Cho

Authors
  1. Myungsun Shim
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  2. Cheryn Song
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  3. Sejun Park
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  4. Seung-Kwon Choi
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Correspondence to Cheryn Song.

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Shim, M., Song, C., Park, S. et al. Prognostic significance of platelet-derived growth factor receptor-β expression in localized clear cell renal cell carcinoma. J Cancer Res Clin Oncol 141, 2213–2220 (2015). https://doi.org/10.1007/s00432-015-2019-x

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  • DOI: https://doi.org/10.1007/s00432-015-2019-x

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