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MiR-345 suppresses proliferation, migration and invasion by targeting Smad1 in human prostate cancer

  • Original Article – Cancer Research
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Abstract

Introduction

The roles of dysregulated microRNAs in prostate cancer metastasis are still unknown. In this study, we found that the expression of miR-345 was significantly downregulated in prostate cancer and clinical prostate cancer tissues.

Materials, methods and results

Overexpression of miR-345 in prostate cancer cells suppressed proliferation, migration and invasion. Using nude mice model, we revealed that miR-345 inhibits the growth of prostate cancer cells in vivo and in vitro. Furthermore, we identified and validated Smad1 as a direct target of miR-345. Ectopic expression of Smad1 without its 3′-UTR rescued miR-345-induced cell migration and invasion inhibition.

Conclusion

Taken together, our data suggest that miR-345 exerts a suppressive effect on prostate cancer proliferation, invasion and migration through downregulation of Smad1.

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Correspondence to Chui-ze Kong.

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Chen, Qg., Zhou, W., Han, T. et al. MiR-345 suppresses proliferation, migration and invasion by targeting Smad1 in human prostate cancer. J Cancer Res Clin Oncol 142, 213–224 (2016). https://doi.org/10.1007/s00432-015-2016-0

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  • DOI: https://doi.org/10.1007/s00432-015-2016-0

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