Skip to main content
Log in

Identification of a novel ETV6 truncated fusion gene in myeloproliferative neoplasm, unclassifiable with t(4;12)(q12;p13)

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Wlodarska I, Mecucci C, Baens M, Marynen P, van den Berghe H (1996) ETV6 gene rearrangements in hematopoietic malignant disorders. Leuk Lymphoma 23(3–4):287–295

    Article  CAS  Google Scholar 

  2. De Braekeleer E, Douet-Guilbert N, Morel F, Le Bris MJ, Basinko A, De Braekeleer M (2012) ETV6 fusion genes in hematological malignancies: a review. Leuk Res 36(8):945–961

    Article  Google Scholar 

  3. Murga Penas EM, Cools J, Algenstaedt P, Hinz K, Seeger D, Schafhausen P et al (2003) A novel cryptic translocation t(12;17)(p13;p12-p13) in a secondary acute myeloid leukemia results in a fusion of the ETV6 gene and the antisense strand of the PER1 gene. Genes Chromosomes Cancer 37(1):79–83

    Article  CAS  Google Scholar 

  4. Odero MD, Vizmanos JL, Roman JP, Lahortiga I, Panizo C, Calasanz MJ et al (2002) A novel gene, MDS2, is fused to ETV6/TEL in a t(1;12)(p36.1;p13) in a patient with myelodysplastic syndrome. Genes Chromosomes Cancer 35(1):11–19

    Article  CAS  Google Scholar 

  5. Suto Y, Sato Y, Smith SD, Rowley JD, Bohlander SK (1997) A t(6;12)(q23;p13) results in the fusion of ETV6 to a novel gene, STL, in a B-cell ALL cell line. Genes Chromosomes Cancer 18(4):254–268

    Article  CAS  Google Scholar 

  6. Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM et al (2016) The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 127(20):2391–2405

    Article  CAS  Google Scholar 

  7. Oikawa T, Yamada T (2003) Molecular biology of the Ets family of transcription factors. Gene. 303:11–34

    Article  CAS  Google Scholar 

  8. Cools J, Mentens N, Odero MD, Peeters P, Wlodarska I, Delforge M, Hagemeijer A, Marynen P (2002) Evidence for position effects as a variant ETV6-mediated leukemogenic mechanism in myeloid leukemias with a t(4;12)(q11-q12;p13) or t(5;12)(q31;p13). Blood. 99(5):1776–1784

    Article  CAS  Google Scholar 

  9. Gianelli U, Cattaneo D, Bossi A, Cortinovis I, Boiocchi L, Liu YC, Augello C, Bonometti A, Fiori S, Orofino N, Guidotti F, Orazi A, Iurlo A (2017) The myeloproliferative neoplasms, unclassifiable: clinical and pathological considerations. Mod Pathol 30(7):1043

    Article  Google Scholar 

Download references

Acknowledgments

All the samples were from Jiangsu Biobank of Clinical Resources.

Funding

This study was supported by grant from the National Key R&D Program of China (2019YFA0111000), the National Natural Science Foundation of China (81,570,138, 81,570,139, 81,600,116, 81,600,114, 81,700,140, 81,873,449, 81,970,142, 81,900,130, 81,970,136), the Natural Science Foundation of the Jiangsu Higher Education Institution of China (18KJA320005), the Natural Science Foundation of Jiangsu Province (BK20190180), China Postdoctoral Science Foundation (2018 M632372), the priority academic program development of Jiangsu Higher Education Institution, the Innovation Capability Development Project of Jiangsu Province (BM2015004), and National Science and Technology Major Project (2017ZX09304021).

Author information

Authors and Affiliations

Authors

Contributions

XFY designed this study. XFY and LM wrote the paper; LZ and MW analyzed RNA-seq data and designed primers; ZW and ZZ collected samples and clinical data; LJW, YX, LM, LY and JNC performed RT-PCR and Sanger sequencing; HZL, JLP, ANS, SNC and DPW gave advice for the study design and paper writing.

Corresponding authors

Correspondence to Liang Ma or Xiaofei Yang.

Ethics declarations

Conflict of interest

The authors declare no competing financial interests.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the First Affiliated Hospital of Soochow University committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

ESM 1

(DOCX 83 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhang, L., Wang, M., Wang, Z. et al. Identification of a novel ETV6 truncated fusion gene in myeloproliferative neoplasm, unclassifiable with t(4;12)(q12;p13). Ann Hematol 99, 2445–2447 (2020). https://doi.org/10.1007/s00277-020-04207-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-020-04207-y

Keywords

Navigation