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Interleukin-10 gene polymorphism in patients with papillary thyroid cancer in Turkish population

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Abstract

Objective: Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that plays a crucial role in the regulation of the immune system. Chronic inflammation has been reported to be a risk factor for thyroid neoplasia. The propensity to mount an inflammatory response is modified by germ line variation in cytokine and other inflammation-related genes. We hypothesized that a proinflammatory genotype would be positively associated with thyroid cancer. We aimed to evaluate the relation between the genotypic and allelic frequencies of the IL-10(-1082 G/A), IL-10(-592 A/C), and IL-10(-819 C/T) polymorphisms, and their association with the risk of developing papillary thyroid cancer (PTC) in the Turkish population. Research design and methods: Forty-two patients with PTC and 113 healthy controls were included in this study. The diagnosis of PTC was confirmed by histopathologic examination after surgery. The evaluation of genotype for IL-10 gene polymorphism was performed using PCR-restriction fragment length polymorphism method. Results: Statistically significant difference IL-10(-1082 G/A) gene polymorphism was determined between 2 (PTC and control) groups. No difference was determined with respect to IL-10(-592 A/C) and IL-10(-819 C/T) gene polymorphisms, and IL-10(-1082 G/A), IL-10(-592 A/C), and IL-10(-819 C/T) allele frequencies of participating between the control group and the patients with PTC (p>0.05). Conclusions: The polymorphism of IL-10(-1082 G/A) gene was significantly associated with the occurrence of PTC. Such studies will contribute significantly to our understanding of the biological role of IL-10(-1082 G/A) gene polymorphism in PTC development. In conclusion, IL-10(-1082 G/A) gene polymorphism may affect the survival of papillary thyroid carcinoma.

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References

  1. Rosai J, Carcangiu ML, De Lellis RA. Atlas of tumor pathology: tumors of the thyroid gland. 3rd series. Washington, DC: Armed Forces Institute of Pathology, 1992.

    Google Scholar 

  2. Sheils O. Molecular classification and biomarker discovery in papillary thyroid carcinoma. Expert Rev Mol Diagn 2005, 5: 927–46.

    Article  PubMed  CAS  Google Scholar 

  3. Finn SP, Smyth P, O’Leary J, Sweeney EC, Sheils O. Ret/PTC chimeric transcripts in an Irish cohort of sporadic papillary thyroid carcinoma. J Clin Endocrinol Metab 2003, 88: 938–41.

    Article  PubMed  CAS  Google Scholar 

  4. Sadetzki S, Calderon-Margalit R, Modan B, Srivastava S, Tuttle RM. Ret/PTC activation in benign and malignant thyroid tumors arising in a population exposed to low-dose external-beam irradiation in childhood. J Clin Endocrinol Metab 2004, 89: 2281–9.

    Article  PubMed  CAS  Google Scholar 

  5. Caudill CM, Zhu Z, Ciampi R, Stringer JR, NikiforovYE. Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to gamma-radiation: a model of carcinogenic chromosomal rearrangement induced by ionizing radiation. J Clin Endocrinol Metab 2005, 90: 2364–9.

    Article  PubMed  CAS  Google Scholar 

  6. Balasubramanian SP, Azmy IA, Higham SE, et al. Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review. BMC Cancer 2006, 6: 188.

    Article  PubMed Central  PubMed  Google Scholar 

  7. El-Omar EM, Rabkin CS, Gammon MD, et al. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology 2003, 124: 1193–201.

    Article  PubMed  CAS  Google Scholar 

  8. Onay VU, Briollais L, Knight JA, et al. SNP-SNP interactions in breast cancer susceptibility. BMC Cancer 2006, 6: 114.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  9. Wang J, Ni H, Chen L, Song WQ. Interleukin-10 promoter polymorphisms in patients with hepatitis B virus infection or hepatocellular carcinoma in Chinese Han ethnic population. Hepatobiliary Pancreat Dis Int 2006, 5: 60–4.

    PubMed  CAS  Google Scholar 

  10. Shin HD, Park BL, Kim LH, et al. Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma. Hum Mol Genet 2003, 12: 901–6.

    Article  PubMed  CAS  Google Scholar 

  11. Eder T, Mayer R, Langsenlehner U, et al. Interleukin-10 [ATA] promoter haplotype and prostate cancer risk: a population-based study. Eur J Cancer 2007, 43: 472–5.

    Article  PubMed  CAS  Google Scholar 

  12. Langsenlehner U, Krippl P, Renner W, et al. Interleukin-10 promoter polymorphism is associated with decreased breast cancer risk. Breast Cancer Res Treat 2005, 90: 113–5.

    Article  PubMed  CAS  Google Scholar 

  13. Havranek E, Howell WM, Fussell HM, Whelan JA, Whelan MA, Pandha HS. An interleukin-10 promoter polymorphism may influence tumor development in renal cell carcinoma. J Urol 2005, 173: 709–12.

    Article  PubMed  CAS  Google Scholar 

  14. Shih CM, Lee YL, Chiou HL, et al. The involvement of genetic polymorphism of IL-10 promoter in non-small cell lung cancer. Lung Cancer 2005, 50: 291–7.

    Article  PubMed  Google Scholar 

  15. Alamartine E, Berthoux P, Mariat C, Cambazard F, Berthoux F. Interleukin-10 promoter polymorphisms and susceptibility to skin squamous cell carcinoma after renal transplantation. J Invest Dermatol 2003, 120: 99–103.

    Article  PubMed  Google Scholar 

  16. Howell WM, Rose-Zerilli MJ. Interleukin-10 polymorphisms, cancer susceptibility and prognosis. Fam Cancer 2006, 5: 143–9.

    Article  PubMed  CAS  Google Scholar 

  17. Nieters A, Beckmann L, Deeg E, Becker N. Gene polymorphisms in Toll-like receptors, interleukin-10, and interleukin-10 receptor alpha and lymphoma risk. Genes Immun 2006, 7: 615–24.

    Article  PubMed  CAS  Google Scholar 

  18. Rothman N, Skibola CF, Wang SS, et al. Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium. Lancet Oncol 2006, 7: 27–38.

    Article  PubMed  CAS  Google Scholar 

  19. Cunningham LM, Chapman C, Dunstan R, Bell MC, Joske DJ. Polymorphisms in the interleukin 10 gene promoter are associated with susceptibility to aggressive non-Hodgkin’s lymphoma. Leuk Lymphoma 2003, 44: 251–5.

    Article  PubMed  CAS  Google Scholar 

  20. Breen EC, Boscardin WJ, Detels R, et al. Non-Hodgkin’s B cell lymphoma in persons with acquired immunodeficiency syndrome is associated with increased serum levels of IL10, or the IL10 promoter-592 C/C genotype. Clin Immunol 2003, 109: 119–29.

    Article  PubMed  CAS  Google Scholar 

  21. Seifart C, Plagens A, Dempfle A, et al. TNF-alpha, TNF-beta, IL-6, and IL-10 polymorphisms in patients with lung cancer. Dis Markers 2005, 21: 157–65.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  22. Shih CM, Lee YL, Chiou HL, et al. The involvement of genetic polymorphism of IL-10 promoter in non-small cell lung cancer. Lung Cancer 2005, 50: 291–7.

    Article  PubMed  Google Scholar 

  23. Wu MS, Wu CY, Chen CJ, Lin MT, Shun CT, Lin JT. Interleukin-10 genotypes associate with the risk of gastric carcinoma in Taiwanese Chinese. IntJ Cancer 2003, 104: 617–23.

    Article  CAS  Google Scholar 

  24. Wang J, Ni H, Chen L, Song WQ. Interleukin-10 promoter polymorphisms in patients with hepatitis B virus infection or hepatocellular carcinoma in Chinese Han ethnic population. Hepatobiliary Pancreat Dis Int 2006, 5: 60–4.

    PubMed  CAS  Google Scholar 

  25. Tseng LH, Lin MT, Shau WY, et al. Correlation of interleukin-10 gene haplotype with hepatocellular carcinoma in Taiwan. Tissue Antigens 2006, 67: 127–33.

    Article  PubMed  CAS  Google Scholar 

  26. Mazur G, Bogunia-Kubik K, Wróbel T, et al. IL-6 and IL-10 promoter gene polymorphisms do not associate with the susceptibility for multiple myeloma. Immunol Lett 2005, 96: 241–6.

    Article  PubMed  CAS  Google Scholar 

  27. Pratesi C, Bortolin MT, Bidoli E, et al. Interleukin-10 and interleukin-18 promoter polymorphisms in an Italian cohort of patients with undifferentiated carcinoma of nasopharyngeal type. Cancer Immunol Immunother 2006, 55: 23–30.

    Article  PubMed  CAS  Google Scholar 

  28. Savage SA, Abnet CC, Haque K, et al. Polymorphisms in interleukin −2, −6, and −10 are not associated with gastric cardia or esophageal cancer in a high-risk chinese population. Cancer Epidemiol Biomarkers Prev 2004, 13: 1547–9.

    PubMed  CAS  Google Scholar 

  29. Todaro M, Zerilli M, Ricci-Vitiani L, et al. Autocrine production of interleukin-4 and interleukin-10 is required for survival and growth of thyroid cancer cells. Cancer Res 2006, 66: 1491–9.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism Disease, Ege University, Medical School, Bornova, Izmir, Turkey

    M. Erdogan MD, M. Karadeniz, M. Ozbek & A. G. Ozgen

  2. Department of Pediatrics, Laboratory of Molecular Medicine, Ege University, Medical School, Bornova, Izmir, Turkey

    A. Berdeli

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  1. M. Erdogan MD
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  2. M. Karadeniz
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  3. M. Ozbek
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  4. A. G. Ozgen
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  5. A. Berdeli
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Correspondence to M. Erdogan MD.

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Erdogan, M., Karadeniz, M., Ozbek, M. et al. Interleukin-10 gene polymorphism in patients with papillary thyroid cancer in Turkish population. J Endocrinol Invest 31, 750–754 (2008). https://doi.org/10.1007/BF03349252

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  • DOI: https://doi.org/10.1007/BF03349252

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