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Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease pp 379–414Cite as

Adherens Junctions and Cancer

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Part of the book series: Subcellular Biochemistry ((SCBI,volume 60))

Abstract

Cadherins and catenins are the central cell–cell adhesion molecules in adherens junctions (AJs). This chapter reviews the knowledge concerning the role of cadherins and catenins in epithelial cancer and examines the published literature demonstrating the changes in the expression and function of these proteins in human cancer and the association of these changes with patient outcomes. The chapter also covers the mechanistic studies aiming at uncovering the significance of changes in cadherin and catenin expression in cancer and potential molecular mechanisms responsible for the causal role of AJs in cancer initiation and progression.

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  1. Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA

    Valeri Vasioukhin

  2. Department of Pathology and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, 98195, USA

    Valeri Vasioukhin

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    Tony Harris

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Vasioukhin, V. (2012). Adherens Junctions and Cancer. In: Harris, T. (eds) Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease. Subcellular Biochemistry, vol 60. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4186-7_16

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