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Advances in Nutrition and Cancer pp 185–205Cite as

Quercetin: A Pleiotropic Kinase Inhibitor Against Cancer

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 159))

Abstract

Increased consumption of fruits and vegetables can represent an easy strategy to significantly reduce the incidence of cancer. From this observation, derived mostly from epidemiological data, the new field of chemoprevention has emerged in the primary and secondary prevention of cancer. Chemoprevention is defined as the use of natural or synthetic compounds able to stop, reverse, or delay the process of tumorigenesis in its early stages. A large number of phytochemicals are potentially capable of simultaneously inhibiting and modulating several key factors regulating cell proliferation in cancer cells. Quercetin is a flavonoid possessing potential chemopreventive properties. It is a functionally pleiotropic molecule, possessing multiple intracellular targets, affecting different cell signaling processes usually altered in cancer cells, with limited toxicity on normal cells. Simultaneously targeting multiple pathways may help to kill malignant cells and slow down the onset of drug resistance. Among the different substrates triggered by quercetin, we have reviewed the ability of the molecule to inhibit protein kinases involved in deregulated cell growth in cancer cells.

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Notes

  1. 1.

    Russo et al. submitted.

Abbreviations

Akt/PKB:

v-akt murine thymoma viral oncogene homolog 1/protein kinase B

PI3K:

Phosphatidylinositol-4,5-bisphosphate 3-kinase

Hck:

Haematopoietic cell kinase

GSK-3β:

Glycogen synthase kinase-3β

Nrf2:

Nuclear factor (erythroid-derived 2)-like 2

NF-κB:

Nuclear factor of kappa light polypeptide gene enhancer in B cells

HO-1:

Heme oxygenase-1

ROS:

Reactive oxygen species

CK2:

Casein kinase 2

Raf-1:

v-raf-1 murine leukemia viral oncogene homolog 1

ERK1/2:

Extracellular signal-regulated kinase 1/2

MEK-1 or MAP2K1:

Mitogen-activated protein kinase kinase 1

PTEN:

Phosphatase and tensin homolog detected on chromosome 10

ΙΚΚα/β:

Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase α/β

ΙκΒα:

Nuclear factor of kappa light polypeptide gene enhancer in B-cell inhibitor, α/β

S6K1:

Ribosomal protein S6 kinase

p90RSK :

90kDa polypeptide

AMPK:

AMP-activated protein kinase

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Authors and Affiliations

  1. Istituto Scienze dell’Alimentazione, Consiglio Nazionale delle Ricerche, 83100, Avellino, Italy

    Gian Luigi Russo, Maria Russo, Carmela Spagnuolo, Idolo Tedesco, Stefania Bilotto & Roberta Iannitti

  2. Istituto Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, 83100, Naples, Italy

    Roberta Iannitti & Rosanna Palumbo

Authors
  1. Gian Luigi Russo
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  2. Maria Russo
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  3. Carmela Spagnuolo
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  4. Idolo Tedesco
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  5. Stefania Bilotto
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  6. Roberta Iannitti
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  7. Rosanna Palumbo
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Correspondence to Gian Luigi Russo .

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Editors and Affiliations

  1. Dept. of Biochemistry and Biophysics, Second University of Naples, Naples, Italy

    Vincenzo Zappia

  2. Clinical and Experimental Medicine, University of Naples "Federico II", Naples, Italy

    Salvatore Panico

  3. Institute of Food Sciences National Research Council, Avellino, Italy

    Gian Luigi Russo

  4. Dept. of Experimental Oncology, National Cancer Institute, Naples, Italy

    Alfredo Budillon

  5. Dept. of Biochemistry and Biophysics, Second University of Naples, Naples, Italy

    Fulvio Della Ragione

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Russo, G.L. et al. (2014). Quercetin: A Pleiotropic Kinase Inhibitor Against Cancer. In: Zappia, V., Panico, S., Russo, G., Budillon, A., Della Ragione, F. (eds) Advances in Nutrition and Cancer. Cancer Treatment and Research, vol 159. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38007-5_11

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  • DOI: https://doi.org/10.1007/978-3-642-38007-5_11

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