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Roles of the Nucleoporin Tpr in Cancer and Aging

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Book cover Cancer Biology and the Nuclear Envelope

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 773))

Abstract

Tpr is a prominent architectural component of the nuclear pore complex that forms the basket-like structure on the nucleoplasmic side of the pore. Tpr, which stands for translocated promoter region, was originally described in the context of oncogenic fusions with the receptor tyrosine kinases Met, TRK, and Raf. Tpr has been since implicated in a variety of nuclear functions, including nuclear transport, chromatin organization, regulation of transcription, and mitosis. More recently, Tpr function has been linked to events including p53 signaling and premature aging in Hutchinson–Gilford Progeria Syndrome (HGPS). Here we provide an overview of the various processes that involve Tpr, and discuss how the levels and localization of a single protein can affect diverse pathways in the cell.

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Abbreviations

APC:

Anaphase promoting complex

EGF:

Epidermal growth factor

HEZ:

Heterochromatin exclusion zone

HGF:

Hepatocyte growth factor

HOS:

Human osteogenic sarcoma

HGPS:

Hutchinson–Gilford progeria syndrome

MSL:

Male-specific lethal

MNNG:

N-methyl-N′-nitronitrosoguanidine

NES:

Nuclear export signal

NLS:

Nuclear localization signal

NPC:

Nuclear pore complex

NUP:

Nucleoporin

SAC:

Spindle assembly checkpoint

TPR:

Translocated promoter region

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Authors and Affiliations

  1. Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA

    Chelsi J. Snow & Bryce M. Paschal

  2. Department of Biochemistry and Molecular Genetics, Health Sciences Center, University of Virginia, Room 7021 West Complex, 1400 Jefferson Park Ave, 800577, Charlottesville, VA, 22908-0577, USA

    Chelsi J. Snow & Bryce M. Paschal

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Correspondence to Bryce M. Paschal .

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Editors and Affiliations

  1. University of Edinburgh Wellcome Trust Centre for Cell Biology, Edinburgh, United Kingdom

    Eric C. Schirmer

  2. University of Edinburgh Wellcome Trust Centre for Cell Biology, Edinburgh, United Kingdom

    Jose I. de las Heras

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Snow, C.J., Paschal, B.M. (2014). Roles of the Nucleoporin Tpr in Cancer and Aging. In: Schirmer, E., de las Heras, J. (eds) Cancer Biology and the Nuclear Envelope. Advances in Experimental Medicine and Biology, vol 773. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-8032-8_14

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