Regular ArticleCD54/ICAM-1 Is a Costimulator of NK Cell-Mediated Cytotoxicity
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Radiation enhances the efficacy of EGFR-targeted CAR-T cells against triple-negative breast cancer by activating NF-κB/Icam1 signaling
2022, Molecular TherapyCitation Excerpt :These results are consistent with the previous studies showing that activated lymphocytes bind to endothelial cells via LFA1/ICAM1 and then transmigrate into tissues.43 ICAM-1 has been reported to be a costimulator of T cells and NK cells mediated cytotoxicity.44,45 In this study, we found that TNBC cells with higher Icam1 expression were killed more rapidly by CAR-T than those with lower or no Icam1 expression.
vIRF3 encoded by Kaposi's sarcoma-associated herpesvirus inhibits T-cell factor-dependent transcription via a CREB-binding protein-interaction motif
2016, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Because transcription of the ICAM-1 promoter is a downstream outcome of NF-κB signaling that is inhibited by vIRF3 thorough interaction with IKK-β, this result is not surprising. However, because activation of the NF-κB signaling pathway is a typical feature of KSHV latent infection and ICAM-1 stimulates the cytotoxic activity of natural killer cells, inhibition of the transcriptional activity of the ICAM-1 promoter by vIRF3 may provide insight into a viral strategy for evading the host immune system [23,24]. A previous study showed that IKK-α specifically increases the transcriptional activity of ICAM-1 promoter in a promoter-dependent and IKK-β–independent manner [25].
Effect of the disintegrin eristostatin on melanoma-natural killer cell interactions
2013, ToxiconCitation Excerpt :McLane et al. (2001) determined that NK-like TALL-104 cytotoxicity levels increased when the TALL-104 cells and melanoma cells were simultaneously treated with eristostatin in addition to the increase seen when only melanoma cells were treated. Natural killer cells can bind target cells through β1 and β2 integrins, including α4β1 RGD-independent), which are selective toward multiple intercellular adhesion molecules (Genego, 2010) and are important for proper adhesion of NK cells to target cells (Chong et al., 1994; Gismondi et al., 2003; Somersalo et al., 1995). In addition to adhesion, activation of α4β1 signaling may also cause the transcription of cytokines, such as interleukin-8, via the mitogen-activated protein kinase pathway, which plays a role in NK cytotoxicity (Mainiero et al., 1998, 2000; Chua et al., 2004).
LFA-1 and CD2 synergize for the Erk1/2 activation in the natural killer (NK) cell immunological synapse
2009, Journal of Biological ChemistryCitation Excerpt :In the process of conjugate formation, integrins and immunoglobulin superfamily molecules were crucial for NK cell adhesion with target cells (13, 20, 34). And different adhesion molecules were employed by different effector cells to adhesion with target cells (13, 20, 35). In our study, CD2 and CD11a, but not CD11c, were accumulated at the interface of NK92-K562 interaction (Fig. 4).
Up regulation of ICAM-1 gene expression inhibits tumour growth and liver metastasis in colorectal carcinoma
2005, European Journal of Cancer