Biochemical and Biophysical Research Communications
Regular ArticleNonredundant Roles of the Elongation Factor MEN in Postimplantation Development
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Cited by (22)
ELL Facilitates RNA Polymerase II–Mediated Transcription of Human Epidermal Proliferation Genes
2021, Journal of Investigative DermatologyRegulation of fertility, survival, and cuticle collagen function by the Caenorhabditis elegans eaf-1 and ell-1 genes
2011, Journal of Biological ChemistryCitation Excerpt :ELL has been identified in an array of species, including yeast (10), Drosophila (11), zebrafish (12), mouse (13), and human (14). This widely expressed gene is essential for embryonic development because deletion of ELL in mouse or Drosophila causes embryonic lethality (15, 16). ELL also plays an important role in leukemia (8, 17).
Elongation factor ELL (eleven-nineteen lysine-rich leukemia) acts as a transcription factor for direct thrombospondin-1 regulation
2009, Journal of Biological ChemistryZebrafish eaf1 and eaf2/u19 mediate effective convergence and extension movements through the maintenance of wnt11 and wnt5 expression
2009, Journal of Biological ChemistryDefective FESTA/EAF2-mediated transcriptional activation in S-II-deficient embryonic stem cells
2007, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Thus, stimulation of transcription elongation by Elongin A and that by S-II might have distinct roles in regulating cellular growth. Other transcription elongation factors, such as ELL and Spt5, are required at specific developmental steps [19,20], suggesting that the transcription of some genes is preferentially affected in the absence of each transcription elongation factor. In yeast S-II mutants, the transcriptional induction of two genes, SDT1/SSM1 and IMD2/PUR5, is specifically impaired in response to nucleotide-depleting drugs such as 6-azauracil and mycophenolic acid [21,22].
FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity
2007, Cancer LettersCitation Excerpt :ELL and EAF1 are components of the Cajal bodies (CB) [21], raising a possibility that FB1 may be also present in the Cajal Bodies. ELL is essential in early animal development because ELL gene knockout in the mouse resulted in embryonic lethality [22]. ELL is also involved in tumor development because MLL–ELL translocation occurs in acute myeloid leukemia.
- 1
Present address: Department of Hematology, Dokkyo University School of Medicine, Tochigi, Japan.
- 2
To whom correspondence should be addressed at Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8655, Japan. Fax: +81-3-5689-7286. E-mail: [email protected].