Hoffman effect

Open Access
Extensive DNA Damage and Loss of Cell Viability Occur Synergistically With the Combination of Recombinant Methioninase and Paclitaxel on Pancreatic Cancer Cells which Report DNA-Damage Response in Real Time
SEI MORINAGA, QINGHONG HAN, KOHEI MIZUTA, BYUNG MO KANG, MOTOKAZU SATO, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

Cancer Genomics & Proteomics November 2024, 21 (6) 585-590; DOI: https://doi.org/10.21873/cgp.20475
Open Access
Induction of the DNA-Repair Gene POLQ only in BRCA1-mutant Breast-Cancer Cells by Methionine Restriction
TOMONARI KUNIHISA, SACHIKO INUBUSHI, HIROKAZU TANINO and ROBERT M. HOFFMAN

Cancer Genomics & Proteomics July 2024, 21 (4) 399-404; DOI: https://doi.org/10.21873/cgp.20458
Open Access
The Combination of Methioninase and Ethionine Exploits Methionine Addiction to Selectively Eradicate Osteosarcoma Cells and Not Normal Cells and Synergistically Down-regulates the Expression of C-MYC
YUSUKE AOKI, YUTARO KUBOTA, QINGHONG HAN, NORIYUKI MASAKI, KOYA OBARA, MICHAEL BOUVET, SANT P. CHAWLA, YASUNORI TOME, KOTARO NISHIDA and ROBERT M. HOFFMAN

Cancer Genomics & Proteomics December 2023, 20 (6suppl) 679-685; DOI: https://doi.org/10.21873/cgp.20415
Open Access
Methionine Restriction Increases Exosome Production and Secretion in Breast Cancer Cells
SACHIKO INUBUSHI, TOMONARI KUNIHISA, SACHIKO MIZUMOTO, SHOTARO INOUE, MAYUKO MIKI, ATSUSHI SUETSUGU, HIROKAZU TANINO and ROBERT M. HOFFMAN

Cancer Genomics & Proteomics September 2023, 20 (5) 412-416; DOI: https://doi.org/10.21873/cgp.20393
Open Access
Oncogenes and Methionine Addiction of Cancer: Role of c-MYC
YUSUKE AOKI, QINGHONG HAN, YUTARO KUBOTA, NORIYUKI MASAKI, KOYA OBARA, YASUNORI TOME, MICHAEL BOUVET, KOTARO NISHIDA and ROBERT M. HOFFMAN

Cancer Genomics & Proteomics March 2023, 20 (2) 165-170; DOI: https://doi.org/10.21873/cgp.20371
Open Access
Oral Installation of Recombinant Methioninase-producing Escherichia coli into the Microbiome Inhibits Colon-cancer Growth in a Syngeneic Mouse Model
YUTARO KUBOTA, QINGHONG HAN, KAZUYUKI HAMADA, YUSUKE AOKI, NORIYUKI MASAKI, KOYA OBARA, ANTON BARANOV, MICHAEL BOUVET, TAKUYA TSUNODA and ROBERT M. HOFFMAN

Cancer Genomics & Proteomics November 2022, 19 (6) 683-691; DOI: https://doi.org/10.21873/cgp.20351

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Hoffman effect