RT Journal Article
SR Electronic
T1 <em>MTA1</em> Is Up-regulated in Colorectal Cancer and Is Inversely Correlated with Lymphatic Metastasis
JF Cancer Genomics - Proteomics
JO Cancer Genomics Proteomics
FD International Institute of Anticancer Research
SP 339
OP 345
VO 12
IS 6
A1 JUN LI
A1 LIN YE
A1 PING-HUI SUN
A1 LUCY SATHERLEY
A1 RACHEL HARGEST
A1 ZHONGTAO ZHANG
A1 WEN G. JIANG
YR 2015
UL http://cgp.iiarjournals.org/content/12/6/339.abstract
AB Background: Metastasis-associated protein 1 (MTA1) plays an important role in tumourigenesis and progression of certain cancer types. In the current study, we analyzed the relationship between MTA1 expression and disease progression of colorectal cancer (CRC). Materials and Methods: CRC tissues (n=93) and adjacent normal colorectal tissues (n=70) were analyzed by quantitative real-time polymerase chain reaction. MTA1 knockdown was established in RKO and HT115 cells using MTA1 siRNA. Results: The expression of MTA1 was significantly increased in CRC tissues compared to paired normal colorectal tissues, but decreased expression of MTA1 was correlated with poor prognosis (higher lymph node involvement stage, TNM stage, local invasion and recurrence) that was associated with increased expression of VEGFC and -D and the receptor VEGFR3. Conclusion: MTA1 is up-regulated in CRC. MTA1 expression is inversely associated with lymphatic metastases and the expression of VEGFC, VEGFD and VEGFR3.