PT  - JOURNAL ARTICLE
AU  - YUE WANG
AU  - HELEN YANG
AU  - JI LUO
AU  - JINNIAN GE
TI  - Impact of <em>PTEN</em> IVS4 Polymorphism (rs3830675) on Cancer Susceptibility: An Updated Meta-analysis
DP  - 2015 Sep 01
TA  - Cancer Genomics - Proteomics
PG  - 263--269
VI  - 12
IP  - 5
4099  - http://cgp.iiarjournals.org/content/12/5/263.short
4100  - http://cgp.iiarjournals.org/content/12/5/263.full
SO  - Cancer Genomics Proteomics2015 Sep 01; 12
AB  - Background/Aim: Phosphatase and tensin homolog (PTEN) acts as a tumor suppressor gene through the action of its phosphatase protein product. We performed a meta-analysis to evaluate their relationship. Materials and Methods: A comprehensive database search was performed. Odds ratios (OR) with 95% confidence intervals (CI) were calculated to assess the association between PTEN IVS4 polymorphism and cancer. Results: The meta-analysis indicated that PTEN IVS4 (−/−) genotype was significantly associated with the risk of cancer (OR=1.47, 95% CI=1.11-1.84), especially for digestive cancer (OR=1.67, 95% CI=1.28-2.18) compared to the (+/+) genotype. Moreover, the (−) allele of PTEN IVS4 polymorphism was also significantly associated with the risk of cancer (OR=1.27, 95% CI=1.14-1.41), especially for digestive cancer (OR=1.42, 95% CI=1.16-1.74) compared to the (+) allele. No significant association was observed between PTEN IVS4 (+/−) genotype and risk of cancer. Conclusion: PTEN IVS4 (−/−) genotype was significantly associated with increased risk of cancer especially for digestive tract cancer compared to the (+/+) genotype. A similar phenomenon was observed in the (−) allele of PTEN IVS4 polymorphism compared to the (+) allele and the recessive effect model.