PT  - JOURNAL ARTICLE
AU  - Gangshi Wang
AU  - Haili Huang
AU  - Jie Gao
AU  - Ping Chen
AU  - Weidi You
AU  - Benyan Wu
AU  - Mengwei Wang
TI  - Tissue Microarray Analysis of Topoisomerase IIα Protein in Gastric Adenocarcinomas: Histogenetic and Prognostic Implications
DP  - 2011 May 01
TA  - Cancer Genomics - Proteomics
PG  - 127--133
VI  - 8
IP  - 3
4099  - http://cgp.iiarjournals.org/content/8/3/127.short
4100  - http://cgp.iiarjournals.org/content/8/3/127.full
SO  - Cancer Genomics Proteomics2011 May 01; 8
AB  - The aim of this study was to: To investigate topoisomerase IIα (topo-IIα) expression and its correlation with clinicopathological parameters in primary gastric cancer patients. Patients and Methods: A tissue microarray including tumor, paired non-tumoral and lymph node metastasis specimens from 210 gastric adenocarcinoma patients was built for immunohistochemical interrogation. The correlation between topo-IIα expression and patient clinicopathological parameters was evaluated by univariate and multivariate analyses. Results: High topo-IIα expression was observed in 30.00% (63/210) of the primary tumors, 25.27% (23/91) of the lymph node metastases and 0.47% (1/210) of the non-tumoral gastric mucosa (p<0.001). Topo-IIα expression in the gastric adenocarcinoma was positively correlated with tumor location (gastric cardia, p<0.001), intestinal histological type (p=0.041), late age onset of gastric adenocarcinoma (≥50 years; p=0.002) and male gender (p=0.038). There was no association with other clinicopathological parameters. No correlation was observed between topo-IIα expression and survival. Conclusion: The prognostic value of topo-IIα in gastric adenocarcinoma remains underdetermined.