PT - JOURNAL ARTICLE AU - L.M. Antón Aparicio AU - V. Medina Villaamil AU - G. Aparicio Gallego AU - I. Santamarina Caínzos AU - R. García Campelo AU - L. Valbuena Rubira AU - S. Vázquez Estévez AU - L. León Mateos AU - J. L. Firvida Perez AU - M. Ramos Vázquez AU - O. Fernández Calvo AU - M. Victoria Bolós TI - Expression of Notch1 to -4 and their Ligands in Renal Cell Carcinoma: A Tissue Microarray Study DP - 2011 Mar 01 TA - Cancer Genomics - Proteomics PG - 93--101 VI - 8 IP - 2 4099 - http://cgp.iiarjournals.org/content/8/2/93.short 4100 - http://cgp.iiarjournals.org/content/8/2/93.full SO - Cancer Genomics Proteomics2011 Mar 01; 8 AB - Background: Mutations in signalling pathways essential for embryonic development often lead to tumourigenesis, as is also true for Notch. The aim of this study was to assess the relationship between Notch1 to -4 and their ligands with anatomopathological features of the patients with renal cell carcinoma (RCC). Materials and Methods: This study investigated the pattern of protein expression in RCC specimens using tissue microarray technology. A total of 80 paraffin-embedded RCC samples were retrospectively analysed together with ACHN and A.704 cell lines. Results: Notch1 showed significant positive correlation with chromophobe RCC, no broken capsule, Furhman grade I and when the number of nodes involved was small [(N=1); p=0.039, 0.016, 0.037 and 0.001, respectively)]. Notch3 showed higher expression when the tumour was located in the right kidney (p=0.048). Conclusion: Notch1 may be useful in the future as a biomarker for the differential diagnosis of different RCC histological subtypes. Notch1 to -3 may also have potential use as a strong prognostic factor.