PT  - JOURNAL ARTICLE
AU  - DAOUD M. MEERZAMAN
AU  - CHUNHUA YAN
AU  - QING-RONG CHEN
AU  - MICHAEL N. EDMONSON
AU  - CARL F. SCHAEFER
AU  - ROBERT J. CLIFFORD
AU  - BARBARA K. DUNN
AU  - LI DONG
AU  - RICHARD P. FINNEY
AU  - CONSTANCE M. CULTRARO
AU  - YING HU
AU  - ZHIHUI YANG
AU  - CU V. NGUYEN
AU  - JENNY M. KELLEY
AU  - SHUANG CAI
AU  - HONGEN ZHANG
AU  - JINGHUI ZHANG
AU  - REBECCA WILSON
AU  - LAUREN MESSMER
AU  - YOUNG-HWA CHUNG
AU  - JEONG A. KIM
AU  - NEUNG HWA PARK
AU  - MYUNG-SOO LYU
AU  - IL HAN SONG
AU  - GEORGE KOMATSOULIS
AU  - KENNETH H. BUETOW
TI  - Genome-wide Transcriptional Sequencing Identifies Novel Mutations in Metabolic Genes in Human Hepatocellular Carcinoma
DP  - 2014 Jan 01
TA  - Cancer Genomics - Proteomics
PG  - 1--12
VI  - 11
IP  - 1
4099  - http://cgp.iiarjournals.org/content/11/1/1.short
4100  - http://cgp.iiarjournals.org/content/11/1/1.full
SO  - Cancer Genomics Proteomics2014 Jan 01; 11
AB  - We report on next-generation transcriptome sequencing results of three human hepatocellular carcinoma tumor/tumor-adjacent pairs. This analysis robustly examined ∼12,000 genes for both expression differences and molecular alterations. We observed 4,513 and 1,182 genes demonstrating 2-fold or greater increase or decrease in expression relative to their normal, respectively. Network analysis of expression data identified the Aurora B signaling, FOXM1 transcription factor network and Wnt signaling pathways pairs being altered in HCC. We validated as differential gene expression findings in a large data set containing of 434 liver normal/tumor sample pairs. In addition to known driver mutations in TP53 and CTNNB1, our mutation analysis identified non-synonymous mutations in genes implicated in metabolic diseases, i.e. diabetes and obesity: IRS1, HMGCS1, ATP8B1, PRMT6 and CLU, suggesting a common molecular etiology for HCC of alternative pathogenic origin.