PT  - JOURNAL ARTICLE
AU  - Carrie Spencer
AU  - John Montalvo
AU  - Sarah R. Mclaughlin
AU  - Brad A. Bryan
TI  - Small Molecule Inhibition of Cytoskeletal Dynamics in Melanoma Tumors Results in Altered Transcriptional Expression Patterns of Key Genes Involved in Tumor Initiation and Progression
DP  - 2011 Mar 01
TA  - Cancer Genomics - Proteomics
PG  - 77--85
VI  - 8
IP  - 2
4099  - http://cgp.iiarjournals.org/content/8/2/77.short
4100  - http://cgp.iiarjournals.org/content/8/2/77.full
SO  - Cancer Genomics Proteomics2011 Mar 01; 8
AB  - Background: Rho kinase signaling plays an important role in the oncogenic process largely through its regulation of F-actin dynamics, and inhibition of this pathway results in reduction in tumor volume and metastasis across a number of tumor types. While the cytoskeletal-regulatory role of Rho kinase has been a topic of in-depth study, the mechanisms linking Rho kinase to altered gene expression are largely unknown. Materials and Methods: Global gene expression analysis was performed on melanoma tumors treated with sham or the small molecule inhibitor Y27632. Results: Inhibition of Rho kinase activity in melanoma tumors results in a statistically significant change in gene transcription of 94 genes, many of which are critically involved in tumor initiation and progression. Conclusion: In addition to regulating tumorigenesis through modulation of the phosphoproteome, Rho kinase signaling also contributes to the regulation of the tumor transcriptome.