@article {Spencer77, author = {Carrie Spencer and John Montalvo and Sarah R. Mclaughlin and Brad A. Bryan}, title = {Small Molecule Inhibition of Cytoskeletal Dynamics in Melanoma Tumors Results in Altered Transcriptional Expression Patterns of Key Genes Involved in Tumor Initiation and Progression}, volume = {8}, number = {2}, pages = {77--85}, year = {2011}, publisher = {International Institute of Anticancer Research}, abstract = {Background: Rho kinase signaling plays an important role in the oncogenic process largely through its regulation of F-actin dynamics, and inhibition of this pathway results in reduction in tumor volume and metastasis across a number of tumor types. While the cytoskeletal-regulatory role of Rho kinase has been a topic of in-depth study, the mechanisms linking Rho kinase to altered gene expression are largely unknown. Materials and Methods: Global gene expression analysis was performed on melanoma tumors treated with sham or the small molecule inhibitor Y27632. Results: Inhibition of Rho kinase activity in melanoma tumors results in a statistically significant change in gene transcription of 94 genes, many of which are critically involved in tumor initiation and progression. Conclusion: In addition to regulating tumorigenesis through modulation of the phosphoproteome, Rho kinase signaling also contributes to the regulation of the tumor transcriptome.}, issn = {1109-6535}, URL = {https://cgp.iiarjournals.org/content/8/2/77}, eprint = {https://cgp.iiarjournals.org/content/8/2/77.full.pdf}, journal = {Cancer Genomics \& Proteomics} }