TY - JOUR T1 - Genotoxic Effect of Two Bleaching Agents on Oral Mucosa JF - Cancer Genomics - Proteomics JO - Cancer Genomics Proteomics SP - 209 LP - 215 VL - 10 IS - 5 AU - EVA KLARIC AU - MATEJ PAR AU - IVONA PROFETA AU - NEVENKA KOPJAR AU - RUZICA ROZGAJ AU - VILENA KASUBA AU - DAVOR ZELJEZIC AU - ZRINKA TARLE Y1 - 2013/09/01 UR - http://cgp.iiarjournals.org/content/10/5/209.abstract N2 - Aim: To analyze the genotoxic effect of two hydrogen peroxide-containing bleaching products on oral mucosal cells. Materials and Methods: The research was conducted on 22 individuals divided into two groups. Group 1 used ZOOM2 and group 2 the Opalescence BOOST bleaching agent. Specimens of the gingival and the upper lip mucosa were obtained before, immediately after, and 72 h after the bleaching procedure and were analyzed using a micronucleus test. Results: Seventy-two hours after bleaching treatment with BOOST, samples collected from the oral mucosa exhibited a statistically significant increase of all genotoxicity markers, with large effect sizes (Cohen’s d>0.8) observed in the total number of micronuclei (MN), number of cells with 3+ MN, karyolysis and bi-nuclear cells. ZOOM2 treatment showed a significant increase, with medium-to-large effect sizes, in the number of cells with 1 MN, karyolysis, nuclear buds and bi-nuclear cells. Conclusion: Both preparations demonstrated potential genotoxic effects. ER -