RT Journal Article SR Electronic T1 Circadian Transcription Profile of Mouse Breast Cancer Under Light-Dark and Dark-Dark Conditions JF Cancer Genomics - Proteomics JO Cancer Genomics Proteomics FD International Institute of Anticancer Research SP 311 OP 322 VO 7 IS 6 A1 EUN-YOUNG OH A1 XIAOMING YANG A1 ALEX FRIEDMAN A1 CHRISTINE M. ANSELL A1 JOVELYN DU-QUITON A1 DINAH F. QUITON A1 PATRICIA A. WOOD A1 WILLIAM J.M. HRUSHESKY YR 2010 UL http://cgp.iiarjournals.org/content/7/6/311.abstract AB The circadian clock exists in virtually every cell and regulates key biological processes in cells and tissues. Even in cancer cells, DNA synthesis, cell division and tumor growth are gated by the circadian clock. This study examined the gene expression profiles of transplanted mouse breast tumor cells under normal light-dark (LD) as well as constant dark (DD) conditions. It was found that the overall percentage of rhythmic transcripts in breast tumor tissue was lower than that in normal tissue. Few transcripts had unaltered rhythmic expression patterns under both LD and DD conditions. Most rhythmic transcripts in DD displayed 12h or shorter periods. These results suggest that in addition to the circadian clock control of gene transcription, altering light, feeding, physical activity and other factors characteristically affect the expression of many genes.