RT Journal Article
SR Electronic
T1 Expression of <em>NFkB1</em>, <em>GADD45A</em> and <em>JNK1</em> in Salivary Gland Carcinomas of Different Histotypes
JF Cancer Genomics - Proteomics
JO Cancer Genomics Proteomics
FD International Institute of Anticancer Research
SP 81
OP 87
VO 10
IS 2
A1 GYULA GŐBEL
A1 ISTVÁN SZANYI
A1 PÉTER RÉVÉSZ
A1 MIKLÓS BAUER
A1 IMRE GERLINGER
A1 ÁRPÁD NÉMETH
A1 ISTVÁN EMBER
A1 KATALIN GOCZE
A1 KATALIN GOMBOS
YR 2013
UL http://cgp.iiarjournals.org/content/10/2/81.abstract
AB The class of salivary gland tumours is very heterogenous, both in a histopathological and clinical sense. Since they are uncommon lesions, their clinical management is still problematic. Molecular mechanisms underlying the development of these cancer types may be fundamental for the diagnosis, treatment and prognosis of this disease. In this study, the gene expression of nuclear factor-kappa B (NKkB1/p65), c-Jun N-terminal kinase (JNK1) and growth arrest and DNA damage (GADD45A), which all play an important role in inflammatory and cell survival mechanisms, was assessed in benign and malignant neoplasms of the salivary gland. The absolute mRNA content of paraffin embedded samples of salivary gland cancer was determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) using specific primers for NFkB1, GADD45A and JNK1. Expression values (relative to HPRT) were statistically evaluated. Among the detected alterations in gene expression, the only difference reaching statistical significance was in the case of NFkB1 in adenocystic carcinomas (p=0.05). Given the importance of these signalling mechanisms in the biology of tumorigenesis, these results may be implemented in further research and these genes might become targets for innovative diagnostic and therapeutic strategies.