RT Journal Article
SR Electronic
T1 Cancer Metabolism: What we Can Learn from Proteomic Analysis by Mass Spectrometry
JF Cancer Genomics - Proteomics
JO Cancer Genomics Proteomics
FD International Institute of Anticancer Research
SP 373
OP 381
VO 9
IS 6
A1 Weidong Zhou
A1 Lance A. Liotta
A1 Emanuel F. Petricoin
YR 2012
UL http://cgp.iiarjournals.org/content/9/6/373.abstract
AB A variety of genomic and proteomic tools have been used to study cancer metabolism and metabolomics in order to understand how cancer cells survive in their environment. Throughout the past decade, mass spectrometry has been routinely used for large-scale protein identification of complex biological mixtures. In this review, we discuss some recent developments in cancer metabolism by proteomic analysis using mass spectrometric techniques, focusing on pyruvate kinase, L-lactate dehydrogenase, Warburg effect, glutamine metabolism and oxidative stress.