RT Journal Article
SR Electronic
T1 The Role of Folate Metabolism-related Gene Polymorphisms in the Development of Meningiomas
JF Cancer Genomics - Proteomics
JO Cancer Genomics Proteomics
FD International Institute of Anticancer Research
SP 105
OP 109
VO 7
IS 2
A1 STEFANOS S. DRAKOS
A1 FOTEINI ANIFANTAKI
A1 APOSTOLOS ZARROS
A1 CHARIS LIAPI
YR 2010
UL http://cgp.iiarjournals.org/content/7/2/105.abstract
AB Meningiomas are (usually) slow-growing benign tumors, and several factors have been implicated in their development. Increasing age, previous exposure to ionizing radiation, endogenous hormone status and history, hormone replacement therapy, genetic variants and polymorphisms are the main factors that have been proven or assumed to be involved in meningioma formation. The complex genetic background supporting the pathogenesis of meningiomas includes a large number of mutations and polymorphisms that might be actively involved in tumor development, progression and recurrence. The aim of this mini-review is to summarize the current data concerning the role of folate metabolism-related gene polymorphisms in the development of meningiomas.