PT  - JOURNAL ARTICLE
AU  - ASTRID ESCUDERO-ESPARZA
AU  - TRACEY A. MARTIN
AU  - MANSEL LEIGH DAVIES
AU  - WEN G. JIANG
TI  - PGF Isoforms, PLGF-1 and PGF-2, in Colorectal Cancer and the Prognostic Significance
DP  - 2009 Jul 01
TA  - Cancer Genomics - Proteomics
PG  - 239--246
VI  - 6
IP  - 4
4099  - http://cgp.iiarjournals.org/content/6/4/239.short
4100  - http://cgp.iiarjournals.org/content/6/4/239.full
SO  - Cancer Genomics Proteomics2009 Jul 01; 6
AB  - Aim: This study examined the expression of PLGF-1 and PGF-2 in human colorectal cancer and how changes in expression may be linked to prognosis of the disease. Materials and Methods: Expression of PLGF transcripts in primary colorectal tumours (n=94) and background tissue (n=80) were analysed by Q-PCR. Immunohistochemistry was carried out on a number of matched background and tumour sections. Results: There was a progressive increase in Dukes A to C (430±134 versus 674±2680) and with TNM 1 to 3 as compared to background tissues (479±152 versus 777±327 p=0.032). Interestingly, there was an increase in PLGF-1 expression in patients with poor outcome compared with patients remaining disease-free. PGF-2 expression was significantly elevated in tumours compared to normal (4558±240 versus 859±67.3 p<0.0001). Moreover, expression was increased in patients with poor prognosis compared to those remaining disease free (4585±285 versus 3909±446). Conclusion: There is increased expression of the PLGF isoforms in human colorectal cancer.