@article {ESCUDERO-ESPARZA239, author = {ASTRID ESCUDERO-ESPARZA and TRACEY A. MARTIN and MANSEL LEIGH DAVIES and WEN G. JIANG}, title = {PGF Isoforms, PLGF-1 and PGF-2, in Colorectal Cancer and the Prognostic Significance}, volume = {6}, number = {4}, pages = {239--246}, year = {2009}, publisher = {International Institute of Anticancer Research}, abstract = {Aim: This study examined the expression of PLGF-1 and PGF-2 in human colorectal cancer and how changes in expression may be linked to prognosis of the disease. Materials and Methods: Expression of PLGF transcripts in primary colorectal tumours (n=94) and background tissue (n=80) were analysed by Q-PCR. Immunohistochemistry was carried out on a number of matched background and tumour sections. Results: There was a progressive increase in Dukes A to C (430{\textpm}134 versus 674{\textpm}2680) and with TNM 1 to 3 as compared to background tissues (479{\textpm}152 versus 777{\textpm}327 p=0.032). Interestingly, there was an increase in PLGF-1 expression in patients with poor outcome compared with patients remaining disease-free. PGF-2 expression was significantly elevated in tumours compared to normal (4558{\textpm}240 versus 859{\textpm}67.3 p\<0.0001). Moreover, expression was increased in patients with poor prognosis compared to those remaining disease free (4585{\textpm}285 versus 3909{\textpm}446). Conclusion: There is increased expression of the PLGF isoforms in human colorectal cancer.}, issn = {1109-6535}, URL = {https://cgp.iiarjournals.org/content/6/4/239}, eprint = {https://cgp.iiarjournals.org/content/6/4/239.full.pdf}, journal = {Cancer Genomics \& Proteomics} }