RT Journal Article SR Electronic T1 Pathogenetic and Clinical Relevance of MicroRNAs in Colorectal Cancer JF Cancer Genomics - Proteomics JO Cancer Genomics Proteomics FD International Institute of Anticancer Research SP 195 OP 204 VO 6 IS 4 A1 NICOLA VALERI A1 CARLO M. CROCE A1 MULLER FABBRI YR 2009 UL http://cgp.iiarjournals.org/content/6/4/195.abstract AB Colorectal cancer (CRC) has been described as a multistep disease due to the progressive accumulation of mutations and chromosomal rearrangements involving critical oncogenes or oncosuppressors. MicroRNAs (miRNAs) are a class of small interfering RNAs frequently involved in the pathogenesis of cancer. Several genome-wide profiling studies have identified miRNAs deregulated in colorectal cancer. Many of these deregulated miRNAs contribute to CRC tumorigenesis and may help to understand CRC pathogenesis, prognosis and response to treatment. This review will focus on common mechanisms involved in miRNA alterations in CRC, their functional implication in CRC development and the potential use of miRNAs as prognostic and predictive surrogate markers for the management of CRC patients.