PT  - JOURNAL ARTICLE
AU  - SMITH, ROBERT A.
AU  - JEDLINSKI, DOMINIK J.
AU  - GABROVSKA, PLAMENA N.
AU  - WEINSTEIN, STEPHEN R.
AU  - HAUPT, LARISA
AU  - GRIFFITHS, LYN R.
TI  - A Genetic Variant Located in miR-423 is Associated with Reduced Breast Cancer Risk
DP  - 2012 May 01
TA  - Cancer Genomics - Proteomics
PG  - 115--118
VI  - 9
IP  - 3
4099  - http://cgp.iiarjournals.org/content/9/3/115.short
4100  - http://cgp.iiarjournals.org/content/9/3/115.full
SO  - Cancer Genomics Proteomics2012 May 01; 9
AB  - Background/Aim: Since microRNAs (miRNAs) act as translational regulators of multiple genes, single nucleotide polymorphisms (SNP) in them can have potentially wide-ranging effects. Using an association approach, this research examined the effects of the rs6505162 SNP, an A>C polymorphism located in the pre-miRNA region of miR-423, on breast cancer development. Materials and Methods: Caucasian Australian women with breast cancer and controls matched for age and ethnicity were genotyped for rs6505162 and their genotypic and allelic frequencies analysed for significant differences. Results: Analysis indicated that there were significant differences between the case and control populations (χ2=6.70, p=0.035), with the CC genotype conferring reduced risk of breast cancer development (odds ratio=0.50 95% confidence interval=0.27-0.92, p=0.03). Conclusion: Further functional research is required to determine the mechanism of action of this SNP on miRNA function.