<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">SMITH, ROBERT A.</style></author><author><style face="normal" font="default" size="100%">JEDLINSKI, DOMINIK J.</style></author><author><style face="normal" font="default" size="100%">GABROVSKA, PLAMENA N.</style></author><author><style face="normal" font="default" size="100%">WEINSTEIN, STEPHEN R.</style></author><author><style face="normal" font="default" size="100%">HAUPT, LARISA</style></author><author><style face="normal" font="default" size="100%">GRIFFITHS, LYN R.</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">A Genetic Variant Located in miR-423 is Associated with Reduced Breast Cancer Risk</style></title><secondary-title><style face="normal" font="default" size="100%">Cancer Genomics - Proteomics</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2012-05-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">115-118</style></pages><volume><style face="normal" font="default" size="100%">9</style></volume><issue><style face="normal" font="default" size="100%">3</style></issue><abstract><style  face="normal" font="default" size="100%">Background/Aim: Since microRNAs (miRNAs) act as translational regulators of multiple genes, single nucleotide polymorphisms (SNP) in them can have potentially wide-ranging effects. Using an association approach, this research examined the effects of the rs6505162 SNP, an A&gt;C polymorphism located in the pre-miRNA region of miR-423, on breast cancer development. Materials and Methods: Caucasian Australian women with breast cancer and controls matched for age and ethnicity were genotyped for rs6505162 and their genotypic and allelic frequencies analysed for significant differences. Results: Analysis indicated that there were significant differences between the case and control populations (χ2=6.70, p=0.035), with the CC genotype conferring reduced risk of breast cancer development (odds ratio=0.50 95% confidence interval=0.27-0.92, p=0.03). Conclusion: Further functional research is required to determine the mechanism of action of this SNP on miRNA function.</style></abstract></record></records></xml>