TY - JOUR T1 - Fully Human Targeted Cytotoxic Fusion Proteins: New Anticancer Agents on the Horizon JF - Cancer Genomics - Proteomics JO - Cancer Genomics Proteomics SP - 119 LP - 133 VL - 9 IS - 3 AU - ULRICH H. WEIDLE AU - GUY GEORGES AU - ULRICH BRINKMANN Y1 - 2012/05/01 UR - http://cgp.iiarjournals.org/content/9/3/119.abstract N2 - Cytotoxic fusion proteins for tumor therapy are composed of an antibody-based targeting moiety and an effector molecule. Effectors may possess enzymatic activity confering cytoxicity after internalization or be an antibody-targeted death-receptor ligand that induces apoptosis after interaction with a death receptor. In this review, we focus on cytotoxic fusion proteins which, in most cases, are composed of fully human targeting and effector moieties. Regarding the first category, as outlined above, we focus on fusion proteins based on ribonucleases, granzyme B, apoptosis-inducing factor and death-associated protein kinases. The second category of fusion proteins makes use of cell-death inducing ligands such as tumor-necrosis factor, tumor necrosis factor α-related, apoptosis-inducing ligand fas ligand and a tumor-targeting antibody moiety. For the latter category, prodrug-related concepts are also covered. The critical issues to be resolved for improved efficacy and safety are discussed. ER -