PT  - JOURNAL ARTICLE
AU  - Jinhua Wu
AU  - Na Xie
AU  - Xia Zhao
AU  - Edouard C. Nice
AU  - Canhua Huang
TI  - Dissection of Aberrant GPCR Signaling in Tumorigenesis – A Systems Biology Approach
DP  - 2012 Jan 01
TA  - Cancer Genomics - Proteomics
PG  - 37--50
VI  - 9
IP  - 1
4099  - http://cgp.iiarjournals.org/content/9/1/37.short
4100  - http://cgp.iiarjournals.org/content/9/1/37.full
SO  - Cancer Genomics Proteomics2012 Jan 01; 9
AB  - The superfamily of G-protein-coupled receptors (GPCRs) is one of the largest mammalian protein families. It is involved in signal transduction and participates in the regulation of normal physiological function and pathological progression of a range of diseases. Recent studies have demonstrated that many aberrant GPCRs and their ligands are associated with tumorigenesis, angiogenesis and metastasis, which provides promising opportunities for drug discovery for cancer prevention and treatment. It is necessary to search for drug targets such as ligands of unknown GPCRs and better modulators of known GPCRs using high throughput screening approaches. Here, we review recent research advances in the identification of novel GPCRs and their protein interactions.