RT Journal Article SR Electronic T1 KRAS Mutation Is Associated with Elevated Myeloblastin Activity in Human Lung Adenocarcinoma JF Cancer Genomics - Proteomics JO Cancer Genomics Proteomics FD International Institute of Anticancer Research SP 51 OP 54 VO 9 IS 1 A1 Thomas Wiedl A1 Stéphane Collaud A1 Sven Hillinger A1 Stephan Arni A1 Chris Burgess A1 Werner Kroll A1 Peter Schraml A1 Alex Soltermann A1 Holger Moch A1 Walter Weder YR 2012 UL http://cgp.iiarjournals.org/content/9/1/51.abstract AB Lung cancer is the leading cause of all cancer deaths worldwide with suboptimal prognosis and treatment options. Therefore this study aimed to identify molecular characteristics with a predictive clinical utility which at the same time might represent novel therapeutic targets for human lung adenocarcinoma. Within this study mutations of v-Ki-RAS2 Kirsten rat sarcoma viral oncogene homolog (KRAS), a gene frequently mutated in lung adenocarcinoma, and their association with enzymatic activities, as assessed by activity-based proteomics, of members of the serine hydrolase (SH) superfamily, a large class of enzymes that have previously been linked to cancer was investigated. The results revealed that the activity of myeloblastin was significantly altered in the lung adenocarcinoma biopsies harboring a KRAS gene mutation. In conclusion myeloblastin is a potential therapeutic target for human lung adenocarcinoma, indicating that the combination of activity-based proteomics with mutational analysis is a valid approach for the discovery of novel biomarkers.