PT  - JOURNAL ARTICLE
AU  - THOMAS KISLINGER
AU  - IGOR JURISICA
TI  - Proteomics and Bioinformatics in Biomedical Research
DP  - 2006 Jan 01
TA  - Cancer Genomics - Proteomics
PG  - 11--28
VI  - 3
IP  - 1
4099  - http://cgp.iiarjournals.org/content/3/1/11.short
4100  - http://cgp.iiarjournals.org/content/3/1/11.full
SO  - Cancer Genomics Proteomics2006 Jan 01; 3
AB  - Proteomics, the science of globally detecting proteins in cells, tissues or organisms under defined conditions, has greatly benefited from recent developments in mass spectrometry (MS). It is now possible to detect hundreds to thousands of proteins with high confidence in a single experiment. In this review, the basic MS technologies, currently used by laboratories around the world to identify proteins in complex biological samples, are summarized. Further, a short overview of useful separation strategies to minimize the initial complexity of biological samples, and the multitude of bioinformatics tools essential to manage large-scale proteomics data to obtain meaningful biological insight, is provided. Finally, recent advances in three main areas of medical proteomics are summarized: proteomics in cancer research, proteomics of the heart and proteomics in diabetes research.