PT  - JOURNAL ARTICLE
AU  - JACQUELINE A. HALL
AU  - ROBERT BROWN
AU  - JIM PAUL
TI  - An Exploration into Study Design for Biomarker Identification: Issues and Recommendations
DP  - 2007 May 01
TA  - Cancer Genomics - Proteomics
PG  - 111--119
VI  - 4
IP  - 3
4099  - http://cgp.iiarjournals.org/content/4/3/111.short
4100  - http://cgp.iiarjournals.org/content/4/3/111.full
SO  - Cancer Genomics Proteomics2007 May 01; 4
AB  - Genomic profiling produces large amounts of data and a challenge remains in identifying relevant biological processes associated with clinical outcome. Many candidate biomarkers have been identified but few have been successfully validated and make an impact clinically. This review focuses on some of the study design issues encountered in data mining for biomarker identification with illustrations of how study design may influence the final results. This includes issues of clinical endpoint use and selection, power, statistical, biological and clinical significance. We give particular attention to study design for the application of supervised clustering methods for identification of gene networks associated with clinical outcome and provide recommendations for future work to increase the success of identification of clinically relevant biomarkers.