PT  - JOURNAL ARTICLE
AU  - REKHA RAI
AU  - GUANG PENG
AU  - KAIYI LI
AU  - SHIAW-YIH LIN
TI  - DNA Damage Response: The Players, the Network and the Role in Tumor Suppression
DP  - 2007 Mar 01
TA  - Cancer Genomics - Proteomics
PG  - 99--106
VI  - 4
IP  - 2
4099  - http://cgp.iiarjournals.org/content/4/2/99.short
4100  - http://cgp.iiarjournals.org/content/4/2/99.full
SO  - Cancer Genomics Proteomics2007 Mar 01; 4
AB  - One of the most common features of cancer is genetic instability. In response to numerous DNA-damaging insults, normal cells have evolved a complex mechanism to monitor and repair DNA damage lesions to maintain genomic integrity. The defects in DNA damage response, indeed, have been shown to associate closely with tumorigenesis. This review provides an overview on the molecular events in DNA damage signaling pathway, including cell cycle checkpoint and DNA repair. The recent research discoveries on how dysfunction in DNA damage response contributes to genomic instability and cancer development are also discussed.