RT Journal Article
SR Electronic
T1 Telomerase: A Crucial Player in HTLV-I-induced Human T-cell Leukemia
JF Cancer Genomics - Proteomics
JO Cancer Genomics Proteomics
FD International Institute of Anticancer Research
SP 21
OP 25
VO 4
IS 1
A1 MARCIA BELLON
A1 CHRISTOPHE NICOT
YR 2007
UL http://cgp.iiarjournals.org/content/4/1/21.abstract
AB One in seven types of human cancer is associated with an oncogenic virus infection. Most human tumors have high telomerase activity but very short telomeres, yet the maintenance of these short telomeres is critical to avoid telomere end fusion or senescence and to support active proliferation. Oncogenic viruses have evolved a wide repertoire of strategies to stimulate telomerase functions at the transcriptional and post-transcriptional levels. Since telomerase activity is absent in somatic cells, the inhibition of telomerase is an attractive target for cancer therapeutics.