PT  - JOURNAL ARTICLE
AU  - LILIAN T. COSTA
AU  - STEFAN THALHAMMER
AU  - WOLFGANG M. HECKL
TI  - Atomic Force Microscopy as a Tool in Nanobiology Part II: Force Spectroscopy in Genomics and Proteomics
DP  - 2004 Jan 01
TA  - Cancer Genomics - Proteomics
PG  - 71--76
VI  - 1
IP  - 1
4099  - http://cgp.iiarjournals.org/content/1/1/71.short
4100  - http://cgp.iiarjournals.org/content/1/1/71.full
SO  - Cancer Genomics Proteomics2004 Jan 01; 1
AB  - We present possible applications of Atomic Force Microscopy (AFM) as a force spectroscopy tool in genomics and proteomics. AFM applications in these fields have opened new opportunities for studying the mechanical properties of biomolecules and their interactions in their native environment, as well as in determining the binding affinity of DNA proteins in dependence with the target DNA sequence for further correlative studies on physical affinity and biological relevance of the controlled gene. Furthermore, force spectroscopy is a powerful analytical tool to investigate structural and functional features of biomolecules. Altogether, these tools have revealed useful application in genomics and proteomics.