RT Journal Article
SR Electronic
T1 Relationship among Genetic Alterations, DNA Content, and Clinicopathological Features in Primary Lung Adenocarcinomas
JF Cancer Genomics - Proteomics
JO Cancer Genomics Proteomics
FD International Institute of Anticancer Research
SP 265
OP 270
VO 3
IS 3-4
A1 UEDA, KAZUHIRO
A1 KANEDA, YOSHIKAZU
A1 HAYASHI, MASATARO
A1 JINBO, MITSUTAKA
A1 LI, TAO-SHENG
A1 HAMANO, KIMIKAZU
YR 2006
UL http://cgp.iiarjournals.org/content/3/3-4/265.abstract
AB Background: Only fragmentary information is available about the genomic imbalances affecting the malignant potential of lung cancers. Patients and Methods: Chromosomal DNA sequence copy number aberrations (DSCNAs) and DNA content (ploidy status) were examined in 34 resected tumor specimens, using comparative genomic hybridization and laser scanning cytometry, respectively. Results: Twenty-seven tumors showed DNA aneuploidy. Gains of 9q22-33 and 10q26-qter and loss of 15q14-qter were the significant indicators of lymph node metastasis. These DSCNAs were identified only in aneuploid tumors. Aneuploid tumors with any of these DSCNAs were associated with a worse prognosis than those not associated with any of these DSCNAs. The DNA index was a significant prognosticator in aneuploid tumors, although it was not dependent on the level of genetic alterations. Conclusion: Clinically-relevant genetic alterations were identified predominantly in aneuploid tumors. The DNA content also affected the prognosis of patients with aneuploid tumors. Thus, a comprehensive genomic study of aneuploid lung adenocarcinomas should be of great clinical value.