RT Journal Article
SR Electronic
T1 Identification of a Novel Long Non-coding RNA, <em>lnc-ATMIN-4:2</em>, and its Clinicopathological and Prognostic Significance in Advanced Gastric Cancer
JF Cancer Genomics - Proteomics
JO Cancer Genomics Proteomics
FD International Institute of Anticancer Research
SP 761
OP 772
DO 10.21873/cgp.20358
VO 19
IS 6
A1 EOJIN KIM
A1 HYUNJIN KIM
A1 MIN-KYUNG YEO
A1 CHUL HWAN KIM
A1 JOO YOUNG KIM
A1 SUNGSOO PARK
A1 HYUN-SOO KIM
A1 YANG-SEOK CHAE
YR 2022
UL http://cgp.iiarjournals.org/content/19/6/761.abstract
AB Background/Aim: Long non-coding RNAs (lncRNAs) are emerging as significant regulators of gene expression and a novel promising biomarker for cancer diagnosis and prognosis. This study identified a novel, differentially expressed lncRNA in advanced gastric cancer (AGC), Inc-ATMIN-4:2, and evaluated its clinicopathological and prognostic significance. Patients and Methods: Whole transcriptome sequencing was performed to identify differentially expressed lncRNAs in AGC tissue samples. We also analyzed lnc-ATMIN-4:2 expression in 317 patients with AGC using RNA in situ hybridization. Results: High (&gt;30 dots) lnc-ATMIN-4:2 expression significantly correlated with younger age, poorly differentiated histology, diffuse type, deeper invasion depth, perineural invasion, lymph node metastasis, and higher stage group. In addition, high lnc-ATMIN-4:2 expression was significantly associated with worse overall survival in patients with AGC. Conclusion: This study elucidated the significance of lncRNAs in AGC and indicated the value of lnc-ATMIN-4:2 expression as a predictive biomarker for the overall survival of patients with AGC.