TY - JOUR T1 - Long Non-coding RNAs With <em>In Vitro</em> and <em>In Vivo</em> Efficacy in Preclinical Models of Esophageal Squamous Cell Carcinoma Which Act by a Non-microRNA Sponging Mechanism JF - Cancer Genomics - Proteomics JO - Cancer Genomics Proteomics SP - 372 LP - 389 DO - 10.21873/cgp.20327 VL - 19 IS - 4 AU - ULRICH H. WEIDLE AU - FABIAN BIRZELE Y1 - 2022/07/01 UR - http://cgp.iiarjournals.org/content/19/4/372.abstract N2 - Esophageal squamous cell carcinoma is a type of cancer with dismal prognosis. Surgery, chemo- and radiation therapy, as well as immune checkpoint-blocking immunotherapy lead to limited improvement of survival of patients; therapy resistance and recurrencies hamper these treatment modalities. Therefore, the identification of new targets and treatment approaches is of paramount importance. We have searched the literature and identified 7 down-regulated and 16 up-regulated non-coding RNAs, which showed efficacy in preclinical esophageal squamous cell carcinoma-related in vitro and in vivo models, and discuss their diverse mode of actions. We excluded long non-coding RNAs, which act by sponging of microRNAs. It is presently unclear whether long non-coding RNA/protein, DNA and RNA interactions can be targeted with small molecules. We describe reconstitution therapy and inhibition of the corresponding long non-coding RNAs with small interfering RNAs and antisense oligonucleotides. Also, we discuss emerging targets for treatment of esophageal squamous cell carcinoma. ER -