RT Journal Article
SR Electronic
T1 MicroRNAs and Corresponding Targets in Esophageal Cancer as Shown <em>In Vitro</em> and <em>In Vivo</em> in Preclinical Models
JF Cancer Genomics - Proteomics
JO Cancer Genomics Proteomics
FD International Institute of Anticancer Research
SP 113
OP 129
DO 10.21873/cgp.20308
VO 19
IS 2
A1 ULRICH H. WEIDLE
A1 ADAM NOPORA
YR 2022
UL http://cgp.iiarjournals.org/content/19/2/113.abstract
AB Squamous cell carcinoma of the esophagus is associated with a dismal prognosis. Therefore, identification of new targets and implementation of new treatment modalities are issues of paramount importance. Based on a survey of the literature, we identified microRNAs conferring antitumoral activity in preclinical in vivo experiments. In the category of miRs targeting secreted factors and transmembrane receptors, four miRs were up-regulated and 10 were down-regulated compared with five out of nine in the category transcription factors, and six miRs were down-regulated in the category enzymes, including metabolic enzymes. The down-regulated miRs have targets which can be inhibited by small molecules or antibody-related entities, or re-expressed by reconstitution therapy. Up-regulated miRs have targets which can be reconstituted with small molecules or inhibited with antagomirs.