TY - JOUR T1 - High Frequency of Juxtamembrane Domain <em>ERBB2</em> Mutation in Gastric Cancer JF - Cancer Genomics - Proteomics JO - Cancer Genomics Proteomics SP - 105 LP - 112 DO - 10.21873/cgp.20307 VL - 19 IS - 1 AU - SUJIN PARK AU - SOOMIN AHN AU - DEOK GEUN KIM AU - HYUNJIN KIM AU - SO YOUNG KANG AU - KYOUNG-MEE KIM Y1 - 2022/01/01 UR - http://cgp.iiarjournals.org/content/19/1/105.abstract N2 - Background/Aim: ERBB2 mutation is an emerging therapeutic target in solid tumors; its therapeutic responses depend on the location of mutation. In gastric cancer, the profiles of ERBB2 mutations and their relationship with human epidermal growth factor receptor 2 (HER2) overexpression remain unknown. We aimed to describe the details of ERBB2 mutations in gastric cancer. Patients and Methods: Comprehensive panel sequencing was performed in 234 advanced gastric cancer patients. We investigated hotspots and clinicopathologic features of ERBB2 mutant gastric cancer in a single institute and evaluated the hotspots of ERBB2 mutation in a public database. Results: Eighteen patients (7.7%) had ERBB2 mutations. The most frequent mutation was p.Arg678Gln (42.1%), which was located in the juxtamembrane domain and was the most common mutation in public databases (20.5%). All 18 ERBB2-mutant patients were negative for HER2 expression. Co-occurring genetic alterations included KRAS, PIK3CA, and ATM mutations. Conclusion: ERBB2 mutations were not associated with HER2 overexpression in gastric cancer patients. The most common mutation was located in the juxtamembrane domain of ERBB2. ER -