@article {HAN699, author = {GWAN HEE HAN and JULIE KIM and HEE YUN and HANBYOUL CHO and JOON-YONG CHUNG and JAE-HOON KIM and STEPHEN M. HEWITT}, title = {CRY1 Regulates Chemoresistance in Association With NANOG by Inhibiting Apoptosis via STAT3 Pathway in Patients With Cervical Cancer}, volume = {18}, number = {6}, pages = {699--713}, year = {2021}, doi = {10.21873/cgp.20291}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: Cryptochrome 1 (CRY1), a core circadian gene, modulates circadian rhythm and carcinogenesis. Here, we investigated the role of CRY1 and its correlation with NANOG, a stem cell transcription factor, in cervical cancer. Materials and Methods: Immunohistochemistry with tissue microarray was performed to evaluate CRY1 and NANOG expression in cervical cancer tissues, and their functional roles were assessed in cervical cancer cell lines. Results: CRY1 or NANOG was significantly over-expressed in cervical cancer tissues. Notably, combined over-expression of CRY1 and NANOG was correlated with a significantly poor OS and DFS and showed a stronger predictive value for chemoradiation response than each single protein. Furthermore, siCRY1 induced apoptosis, decreased NANOG expression, suppressed STAT3 signalling, and activated p53 signalling in cervical cancer cell lines. Conclusion: CRY1 and NANOG over-expression serves as a strong predictive biomarker for prognosis and chemoradiation response, and may be a new therapeutic target in patients with cervical cancer.}, issn = {1109-6535}, URL = {https://cgp.iiarjournals.org/content/18/6/699}, eprint = {https://cgp.iiarjournals.org/content/18/6/699.full.pdf}, journal = {Cancer Genomics \& Proteomics} }