RT Journal Article SR Electronic T1 Biological Effect of Silver-modified Nanostructured Titanium Dioxide in Cancer JF Cancer Genomics - Proteomics JO Cancer Genomics Proteomics FD International Institute of Anticancer Research SP 425 OP 439 DO 10.21873/cgp.20269 VO 18 IS 3 Suppl A1 NEFELI LAGOPATI A1 ATHANASSIOS KOTSINAS A1 DIMITRIS VEROUTIS A1 KONSTANTINOS EVANGELOU A1 ANGELOS PAPASPYROPOULOS A1 MICHALIS ARFANIS A1 POLYCARPOS FALARAS A1 PARASKEVI V. KITSIOU A1 IOANNIS PATERAS A1 ANNA BERGONZINI A1 TERESA FRISAN A1 SPYRIDON KYRIAZIS A1 DIMITRIOS S. TSOUKLERIS A1 EFFIE-PHOTINI C. TSILIBARY A1 MARIA GAZOULI A1 EVANGELIA A. PAVLATOU A1 VASSILIS G. GORGOULIS YR 2021 UL http://cgp.iiarjournals.org/content/18/3_Suppl/425.abstract AB Background/Aim: Nanomedicine is a promising scientific field that exploits the unique properties of innovative nanomaterials, providing alternative solutions in diagnostics, prevention and therapeutics. Titanium dioxide nanoparticles (TiO2 NPs) have a great spectrum of photocatalytic antibacterial and anticancer applications. The chemical modification of TiO2 optimizes its bioactive performance. The aim of this study was the development of silver modified NPs (Ag/TiO2 NPs) with anticancer potential. Materials and Methods: Ag/TiO2 NPs were prepared through the sol-gel method, were fully characterized and were tested on cultured breast cancer epithelial cells (MCF-7 and MDA-MB-231). The MTT colorimetric assay was used to estimate cellular viability. Western blot analysis of protein expression along with a DNA-laddering assay were employed for apoptosis detection. Results and Conclusion: We show that photo-activated Ag/TiO2 NPs exhibited significant cytotoxicity on the highly malignant MDA-MB-231 cancer cells, inducing apoptosis, while MCF-7 cells that are characterized by low invasive properties were unaffected under the same conditions.