TY - JOUR T1 - Biological Effect of Silver-modified Nanostructured Titanium Dioxide in Cancer JF - Cancer Genomics - Proteomics JO - Cancer Genomics Proteomics SP - 425 LP - 439 DO - 10.21873/cgp.20269 VL - 18 IS - 3 Suppl AU - NEFELI LAGOPATI AU - ATHANASSIOS KOTSINAS AU - DIMITRIS VEROUTIS AU - KONSTANTINOS EVANGELOU AU - ANGELOS PAPASPYROPOULOS AU - MICHALIS ARFANIS AU - POLYCARPOS FALARAS AU - PARASKEVI V. KITSIOU AU - IOANNIS PATERAS AU - ANNA BERGONZINI AU - TERESA FRISAN AU - SPYRIDON KYRIAZIS AU - DIMITRIOS S. TSOUKLERIS AU - EFFIE-PHOTINI C. TSILIBARY AU - MARIA GAZOULI AU - EVANGELIA A. PAVLATOU AU - VASSILIS G. GORGOULIS Y1 - 2021/05/01 UR - http://cgp.iiarjournals.org/content/18/3_Suppl/425.abstract N2 - Background/Aim: Nanomedicine is a promising scientific field that exploits the unique properties of innovative nanomaterials, providing alternative solutions in diagnostics, prevention and therapeutics. Titanium dioxide nanoparticles (TiO2 NPs) have a great spectrum of photocatalytic antibacterial and anticancer applications. The chemical modification of TiO2 optimizes its bioactive performance. The aim of this study was the development of silver modified NPs (Ag/TiO2 NPs) with anticancer potential. Materials and Methods: Ag/TiO2 NPs were prepared through the sol-gel method, were fully characterized and were tested on cultured breast cancer epithelial cells (MCF-7 and MDA-MB-231). The MTT colorimetric assay was used to estimate cellular viability. Western blot analysis of protein expression along with a DNA-laddering assay were employed for apoptosis detection. Results and Conclusion: We show that photo-activated Ag/TiO2 NPs exhibited significant cytotoxicity on the highly malignant MDA-MB-231 cancer cells, inducing apoptosis, while MCF-7 cells that are characterized by low invasive properties were unaffected under the same conditions. ER -