RT Journal Article
SR Electronic
T1 Interaction of DNA Repair Gene XPC With Smoking and Betel Quid Chewing Behaviors of Oral Cancer
JF Cancer Genomics - Proteomics
JO Cancer Genomics Proteomics
FD International Institute of Anticancer Research
SP 441
OP 449
DO 10.21873/cgp.20270
VO 18
IS 3 Suppl
A1 CHENG-NAN WU
A1 WEN-SHIN CHANG
A1 LIANG-CHUN SHIH
A1 YUN-CHI WANG
A1 HSU-TUNG LEE
A1 CHIEN-CHIH YU
A1 ZHI-HONG WANG
A1 MEI-CHIN MONG
A1 TE-CHUN HSIA
A1 CHIA-WEN TSAI
A1 DA-TIAN BAU
YR 2021
UL http://cgp.iiarjournals.org/content/18/3_Suppl/441.abstract
AB Background/Aim: Xeroderma pigmentosum complementation group C (XPC) is reported to play important roles in DNA integrity and genomic instability, however, the contribution of XPC to oral carcinogenesis is largely uncertain. Therefore, we aimed at examining the contribution of XPC genotypes to oral cancer. Materials and Methods: The genotypes of XPC rs2228001 and rs2228000 were examined among 958 oral cancer patients and 958 control subjects by polymerase chain reaction-restriction fragment length polymorphism methodology and corresponding DNA repair capacity was checked. Results: First, the percentages of XPC rs2228001 AC and CC were higher among oral cancer patients than controls. Second, no significant association was observed regarding XPC rs2228000. Third, there was a synergistic influence of smoking and betel quid chewing behaviors and XPC rs2228001 genotype on oral cancer risk. Last, functional experiments showed DNA repair capacity was lower for AC/CC carriers than AA carriers. Conclusion: XPC rs2228001 C allele, which was associated with decreased DNA repair capacity, may interact with smoking and betel quid chewing behaviors on oral cancer risk.