TY - JOUR T1 - Contribution of <em>Matrix Metalloproteinase-1</em> Genotypes to Colorectal Cancer in Taiwan JF - Cancer Genomics - Proteomics JO - Cancer Genomics Proteomics SP - 245 LP - 251 DO - 10.21873/cgp.20255 VL - 18 IS - 3 AU - MING-HSIEN WU AU - TE-CHENG YUEH AU - WEN-SHIN CHANG AU - CHIA-WEN TSAI AU - CHUN-KAI FU AU - MEI-DUE YANG AU - CHIEN-CHIH YU AU - DA-TIAN BAU Y1 - 2021/05/01 UR - http://cgp.iiarjournals.org/content/18/3/245.abstract N2 - Background/Aim: Matrix metalloproteinase-1 is responsible for extracellular matrix regulation, and its genetic role in colorectal cancer (CRC) is unclear. The aim of the study was to investigate the contribution of Matrix metalloproteinase-1 genotypes to CRC risk in Taiwan. Materials and Methods: A total of 362 cases and 362 controls were included and their MMP-1 -1607 (rs1799705) genotypes were examined. The environmental factors and clinical-pathological records were also analyzed. Results: The genotypic frequency of MMP-1 rs1799750 were different between the CRC and control groups (p for trend=0.0083). 1G/2G and 1G/1G were associated with lower risk (p=0.0438 and 0.0030, adjusted OR=0.73 and 0.54, 95%CI=0.54-0.90 and 0.37-0.83). Among non-smokers, those with 1G/2G and 1G/1G genotypes were at 0.70- and 0.48-fold odds of having CRC. Among non-alcohol drinkers, people with 1G/2G and 1G/1G genotypes were at 0.71- and 0.54-fold odds. The 1G/1G genotypes were statistically lower among CRC patients with lymph node metastasis (7.2%) than those without (19.0%). Conclusion: The genotypes at MMP-1 rs1799705 play a role in determining susceptibility to CRC risk in Taiwan. ER -