TY - JOUR T1 - Fucoxanthinol Induces Apoptosis in a Pancreatic Intraepithelial Neoplasia Cell Line JF - Cancer Genomics - Proteomics JO - Cancer Genomics Proteomics SP - 133 LP - 146 DO - 10.21873/cgp.20248 VL - 18 IS - 2 AU - MASARU TERASAKI AU - TAKUYA INOUE AU - WATARU MURASE AU - ATSUHITO KUBOTA AU - HIROYUKI KOJIMA AU - MARESHIGE KOJOMA AU - TOHRU OHTA AU - HAYATO MAEDA AU - KAZUO MIYASHITA AU - MICHIHIRO MUTOH AU - MAMI TAKAHASHI Y1 - 2021/03/01 UR - http://cgp.iiarjournals.org/content/18/2/133.abstract N2 - Background/Aim: Fucoxanthinol (FxOH), a predominant metabolite from fucoxanthin (Fx), can exert potential anti-cancer effects in various cancers. However, limited data are available on the effect of FxOH or Fx on pancreatic cancer. The present study investigated the effect of FxOH on a cell line derived from pancreatic cancer tissue developed in Ptf1aCre/+; LSL-k-rasG12D/+ mice. Materials and Methods: Using flow-cytometric, microarrays, and western blotting analyses, alterations in FxOH-induced apoptosis-related gene expression and protein levels were evaluated in a mice pancreatic cancer cell line, KMPC44. Results: FxOH significantly arrested the cells at S phase along with suppression of many gene sets, such as cytokine– cytokine receptor interaction and cell adhesion molecule CAMS. Moreover, attenuated protein levels for cytokine receptors, adhesion, phosphatidylinositol-3 kinase/protein kinase B, and mitogen-activated protein kinase were observed. Conclusion: FxOH may prevent pancreatic cancer development in a murine cancer model. ER -